Liang K C, Juler R G, McGaugh J L
Brain Res. 1986 Mar 12;368(1):125-33. doi: 10.1016/0006-8993(86)91049-8.
These experiments examined the effects, on retention, of posttraining intra-amygdala administration of norepinephrine (NE), and propranolol. Rats were trained on a one-trial step-through inhibitory avoidance task and tested for retention 24 h later. Injections were administered bilaterally (1.0 microliter/injection) through chronically-implanted cannulae. Low doses of NE (0.1 or 0.3 microgram) administered shortly after training enhanced retention while higher doses (1.0 or 5.0 micrograms) were ineffective. Retention was not affected by NE administered 3 h after training. The effect of intra-amygdala NE on retention is blocked by simultaneous administration of propranolol (0.2 microgram). This finding suggests that the memory-enhancing effect of NE may be mediated by beta-receptors. Posttraining intra-amygdala NE also attenuated the retention deficit produced by adrenal demedullation. Further, intra-amygdala injections of propranolol (0.2 microgram) blocked the enhancing effect, on retention, of posttraining s.c. injections of epinephrine. These findings suggest that activation of noradrenergic receptors in the amygdala may be involved in memory processing and may play a role in the memory-modulating effect of peripheral epinephrine.
这些实验研究了训练后杏仁核内注射去甲肾上腺素（NE）和普萘洛尔对记忆保持的影响。大鼠接受单次步通抑制性回避任务训练，并在24小时后进行记忆保持测试。通过长期植入的套管进行双侧注射（1.0微升/注射）。训练后不久注射低剂量的NE（0.1或0.3微克）可增强记忆保持，而高剂量（1.0或5.0微克）则无效。训练3小时后注射NE对记忆保持没有影响。杏仁核内注射NE对记忆保持的作用可被同时注射普萘洛尔（0.2微克）阻断。这一发现表明，NE的记忆增强作用可能是由β受体介导的。训练后杏仁核内注射NE还可减轻肾上腺髓质切除所致的记忆保持缺陷。此外，杏仁核内注射普萘洛尔（0.2微克）可阻断训练后皮下注射肾上腺素对记忆保持的增强作用。这些发现表明，杏仁核中去甲肾上腺素能受体的激活可能参与记忆处理，并可能在外周肾上腺素的记忆调节作用中发挥作用。
