Roozendaal B, Portillo-Marquez G, McGaugh J L
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697-3800, USA.
Behav Neurosci. 1996 Oct;110(5):1074-83. doi: 10.1037//0735-7044.110.5.1074.
This study examined the role of the amygdala in mediating the effects of glucocorticoids on spatial memory in rats. Adrenalectomy (ADX) induced 4-5 days prior to training impaired memory in a water-maze spatial task. This effect was reversed by a posttraining injection of dexamethasone (0.3 mg/kg sc) but not by corticosterone (0.3 mg/kg). Lesions of the basolateral (BLA), but not the central (CEA) or the medial (MEA), amygdala blocked the effects of ADX and dexamethasone. ADX also impaired acquisition. CEA, MEA, and BLA lesions blocked the ADX effect on acquisition. In adrenally intact rats, intracerebroventricular posttraining injections of a specific glucocorticoid receptor (GR or Type-II) antagonist impaired retention, and BLA lesions blocked the effect of the GR antagonist. These findings provide evidence that the BLA is involved in mediating glucocorticoid influences on learning and memory.
本研究考察了杏仁核在介导糖皮质激素对大鼠空间记忆影响中的作用。在训练前4 - 5天进行肾上腺切除术（ADX）会损害水迷宫空间任务中的记忆。训练后注射地塞米松（0.3 mg/kg皮下注射）可逆转此效应，但注射皮质酮（0.3 mg/kg）则不能。基底外侧杏仁核（BLA）损伤而非中央杏仁核（CEA）或内侧杏仁核（MEA）损伤可阻断ADX和地塞米松的效应。ADX也损害记忆获得。CEA、MEA和BLA损伤可阻断ADX对记忆获得的影响。在肾上腺功能正常的大鼠中，训练后脑室内注射特异性糖皮质激素受体（GR或II型）拮抗剂会损害记忆保持，且BLA损伤可阻断GR拮抗剂的效应。这些发现提供了证据，表明BLA参与介导糖皮质激素对学习和记忆的影响。
