Petragnani N, Brocksom T, Moro A
Farmaco Sci. 1977 Jul;32(7):512-21. doi: 10.1002/chin.197751259.
The preparation of 2-formyl-1.4-benzodioxane by reduction of the corresponding ethyl ester, and some reactions of this aldehyde carried out with the aim of obtaining new pharmacologically active derivatives, are described. Wittig reactions with stabilized, semi-stabilized, and reactive phosphoranes resulted in the formation of the 2-alkenyl derivatives. Reaction with a primary amine led to the corresponding imine. The 1.3-dithiane was also prepared and its behaviour with strong bases and alkylating reagents investigated.
描述了通过相应的乙酯还原制备2-甲酰基-1,4-苯并二恶烷，以及为获得新的药理活性衍生物而对该醛进行的一些反应。与稳定、半稳定和活性膦叶立德的维蒂希反应导致形成2-烯基衍生物。与伯胺反应生成相应的亚胺。还制备了1,3-二硫戊环，并研究了其与强碱和烷基化试剂的反应行为。
