Labrid C
IRIS, Courbevoie, France.
Int Angiol. 1995 Sep;14(3 Suppl 1):36-8.
The lymphagogue activity of a micronized, purified flavonoidic fraction, Daflon 500 mg (D) (diosmin 90%+ hesperidin 10%) was tested in dogs and rats.
In the anaesthetized mongrel dog measurement of lymphatic flow was carried out in a thoracic duct fistula inserted 30 min prior to I.V. injection of D (3.125; 6.250 and 12.500 mg/kg-1). Lymph was collected every 10 min for 200 min. Using the same experimental model 14C-diosmin transfer from blood to lymph was studied after I.V. infusion (5 min) of 14C-diosmin (50 muCi)+D(12.5 mg/kg-1) in the saphenous vein. Similar experiments were performed in the rat after oral treatment.
D induced an important lymphatic flow increase which was correlated with the administered doses. The maximal 10 min period flow after I.V. injection of D (12.500 mg/kg-1) was 191% higher than the corresponding one in the control group. A correlation between lymphatic flow increase and pulsatility was demonstrated. Infusion of 14C-labelled-D evidenced a clear blood-lymph transfer of the drug: an active transport into the lymph was suggested during a 15 min-100 min period from the concentration curves.
The improvement of lymphatic drainage displayed by D seems to be an important component of its beneficial effect on perivascular edema.
对一种微粉化的纯化类黄酮组分达弗隆500毫克（D）（地奥司明90%+橙皮苷10%）在犬和大鼠身上进行了促淋巴生成活性测试。
在麻醉的杂种犬身上，于静脉注射D（3.125；6.250和12.500毫克/千克-1）前30分钟插入胸导管瘘管来测量淋巴流量。每10分钟收集淋巴液，共收集200分钟。使用相同的实验模型，在隐静脉静脉输注（5分钟）14C-地奥司明（50微居里）+D（12.5毫克/千克-1）后，研究14C-地奥司明从血液到淋巴的转移。在大鼠口服给药后进行了类似实验。
D引起显著的淋巴流量增加，且与给药剂量相关。静脉注射D（12.500毫克/千克-1）后最大的10分钟流量比对照组相应流量高191%。证明了淋巴流量增加与搏动性之间的相关性。输注14C标记-D证明该药物有明显的血淋巴转移：从浓度曲线来看，在15分钟至100分钟期间提示有主动转运进入淋巴。
D所显示的淋巴引流改善似乎是其对血管周围水肿有益作用的一个重要组成部分。
