Orefice Raffaele, Litta Francesco, Parello Angelo, De Simone Veronica, Campennì Paola, Marra Angelo Alessandro, Ratto Carlo
Proctology Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy.
Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Rome, Italy.
J Clin Med. 2021 Apr 7;10(8):1549. doi: 10.3390/jcm10081549.
The aims of this study were to evaluate the efficacy of two different phlebotonic therapies, preoperatively administered in advanced hemorrhoidal disease (HD) patients with recommendation for surgery, and to assess patient satisfaction after treatment. In this prospective observational study, 100 patients were preoperatively treated either with micronized purified flavonoid fraction (group A) or sublingual nano-emulsion flavonoid (group B). HD symptoms, local inflammation signs and patients' satisfaction were evaluated at baseline visit (T0), after 4 weeks of therapy (T1) and 8 weeks after its discontinuation (T2). In group A, a significant improvement for all HD symptoms and inflammation signs was observed after therapy (T1), followed by a reduction of efficacy in T2, except for itching and edema. In group B, therapy had a significant benefit on symptoms and local inflammation at T1, which persisted after its discontinuation for all symptoms, and edematous hemorrhoids. In both groups, the satisfaction rate was "good" in 60% of patients and patients were statistically significant more satisfied at T1 compared with T2 ( = 0.0001). No adverse events were recorded. Preoperative treatment was safe and useful to optimize patients' clinical condition prior to surgery.
本研究的目的是评估两种不同的促静脉回流疗法在有手术指征的晚期痔病（HD）患者术前应用的疗效，并评估治疗后患者的满意度。在这项前瞻性观察研究中，100例患者术前分别接受微粉化纯化黄酮类成分治疗（A组）或舌下纳米乳剂黄酮治疗（B组）。在基线访视（T0）、治疗4周后（T1）以及停药8周后（T2）评估HD症状、局部炎症体征和患者满意度。在A组，治疗后（T1）所有HD症状和炎症体征均有显著改善，随后在T2疗效降低，但瘙痒和水肿除外。在B组，治疗在T1时对症状和局部炎症有显著益处，停药后所有症状及水肿性痔的改善仍持续存在。在两组中，60%的患者满意度为“良好”，且与T2相比，患者在T1时的满意度在统计学上有显著提高（P = 0.0001）。未记录到不良事件。术前治疗对于优化患者术前临床状况是安全且有用的。
