Farina C, Caprioli A, Luzzi I, Sonzogni A, Goglio A
Servizio di Microbiologia, Istituto Superiore di Sanita, Roma, Italy.
Ital J Gastroenterol. 1995 Dec;27(9):498-500.
The aetiology of ulcerative colitis remains unknown, despite extensive research into likely causes, such as infections, diet, environmental factors, immunological or genetic defects, psychomotor disorders, and abnormalities of mucin. We report here a case of ulcerative colitis in which the first episode of the disease was associated with serologic evidence of infection by verocytotoxin (VT)-producing O157 Escherichia coli (VTEC), possibly the trigger factor of a previously silent ulcerative colitis. Although histological reports of ulcerative colitis associated with VTEC infection are sporadically reported, the trigger role of VTEC in precipitating, aggravating or prolonging this pathology should be more fully elucidated.
尽管对溃疡性结肠炎的可能病因，如感染、饮食、环境因素、免疫或基因缺陷、精神运动障碍以及粘蛋白异常等进行了广泛研究，但其病因仍不明确。我们在此报告一例溃疡性结肠炎病例，该疾病的首发与产志贺毒素（VT）的O157大肠杆菌（VTEC）感染的血清学证据相关，VTEC可能是先前隐匿性溃疡性结肠炎的触发因素。虽然散见有与VTEC感染相关的溃疡性结肠炎的组织学报告，但VTEC在引发、加重或延长这种病理状况中的触发作用仍需更充分地阐明。
