Plachy J, Karakoz I, Geryk J, Hala K
Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague.
Exp Clin Immunogenet. 1995;12(4):272-82.
The oncogenic potential of different strains of Rous sarcoma virus (RSV) varies significantly in two Mhc(B) congenic chicken lines CB and CC and in their F1 hybrids with the unrelated inbred line IA. The Bryan high-titer pseudotype of RSV of antigenic subgroups D and B (BH-D, and BH-B) was highly oncogenic, eliciting mostly fatal, progressively growing tumors. Visceral tumor formation and erythroblastosis were seen after challenge with BH-B in CB and CC chickens, but not in their F1 hybrids with IA. Tumor regression induced by a low-oncogenic RSV strain PR-C elicited a protective immunity capable of preventing not only the progressive growth of challenge tumors at the site of inoculation, but also visceral tumor formation and erythroblastosis.
不同株劳斯肉瘤病毒（RSV）的致癌潜力在两个Mhc（B）同源鸡系CB和CC及其与无关近交系IA的F1杂种中存在显著差异。抗原亚组D和B的RSV布莱恩高滴度假型（BH-D和BH-B）具有高度致癌性，引发的大多是致命的、进行性生长的肿瘤。用BH-B攻击CB和CC鸡后可见内脏肿瘤形成和红细胞增多症，但在它们与IA的F1杂种中未出现。低致癌性RSV株PR-C诱导的肿瘤消退引发了一种保护性免疫，不仅能够防止接种部位攻击肿瘤的进行性生长，还能防止内脏肿瘤形成和红细胞增多症。
