Råstam L, Lindberg G, Folsom A R, Burke G L, Nilsson-Ehle P, Lundblad A
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA.
Int J Epidemiol. 1996 Oct;25(5):953-8. doi: 10.1093/ije/25.5.953.
Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atherosclerosis was evaluated.
From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-media wall thickness above the 90th percentile (measured with B-mode ultrasound) were matched 1:1 with controls without atherosclerosis. Serum sialic acid, plasma LDL and HDL cholesterol, serum insulin concentrations, blood pressure, antihypertensive medication use, and smoking status were used to assess the independent contribution of the sialic acid level to carotid atherosclerosis.
The mean (SD) serum sialic acid concentration was 75.0 (9.7) mg/dl in cases and 70.7 (8.9) mg/dl in controls (P = 0.0001). In a conditional logistic model with adjustment for age, LDL-cholesterol, HDL-cholesterol, serum insulin, smoking and hypertension, the odds ratio associated with sialic acid above the 75th percentile (> or = 78.3 mg/dl) versus below was 1.65 with a 95% confidence interval of 1.01-2.70.
The sialic acid level is correlated with the presence of carotid atherosclerosis, independently of major cardiovascular disease risk factors. The biological mechanism behind this association is not resolved.
既往研究表明，血清唾液酸水平与冠心病和中风死亡率呈正相关。本研究评估了其与颈动脉粥样硬化的关系。
从社区动脉粥样硬化风险（ARIC）研究中，选取323例颈动脉内膜中层厚度高于第90百分位数（通过B型超声测量）的患者，与无动脉粥样硬化的对照组进行1:1匹配。采用血清唾液酸、血浆低密度脂蛋白和高密度脂蛋白胆固醇、血清胰岛素浓度、血压、降压药物使用情况及吸烟状况，评估唾液酸水平对颈动脉粥样硬化的独立影响。
病例组血清唾液酸浓度均值（标准差）为75.0（9.7）mg/dl，对照组为70.7（8.9）mg/dl（P = 0.0001）。在对年龄、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血清胰岛素、吸烟和高血压进行校正的条件逻辑回归模型中，唾液酸高于第75百分位数（≥78.3 mg/dl）与低于该水平相比的优势比为1.65，95%置信区间为1.01 - 2.70。
唾液酸水平与颈动脉粥样硬化的存在相关，独立于主要心血管疾病风险因素。这种关联背后的生物学机制尚未明确。
