Henry-Amar M
Calvados General Tumour Registry & Clinical Research Unit, Centre François, Caen, France.
Baillieres Clin Haematol. 1996 Sep;9(3):595-618. doi: 10.1016/s0950-3536(96)80029-1.
Hodgkin's disease is considered a curable disease. The use of appropriate staging techniques and treatment methods has resulted to long-term cause-specific survival rates as high as 90% in early stages, 75% or greater in advanced stages. Long-surviving Hodgkin's disease patients, however, face new problems which have become apparent as greater numbers of successfully treated patients are followed for longer periods of time. These problems mostly concern chronic medical as well as psychosocial complications which can interfere with survivors' quality of life. Specific therapy may result in severe infections, thyroid, cardiovascular, pulmonary, digestive or gonadal dysfunction. It may also result in secondary malignancy which is considered the most serious complication. Because the vast majority of patients who achieve remission will remain symptom-free and do enjoy a normal life, long-term follow-up should concentrate on prevention and early detection of treatment-related complications and of secondary malignancy.
霍奇金淋巴瘤被认为是一种可治愈的疾病。采用适当的分期技术和治疗方法，早期患者长期特定病因生存率高达90%，晚期患者则为75%或更高。然而，随着越来越多成功治疗的患者接受更长时间的随访，长期存活的霍奇金淋巴瘤患者面临着一些新出现的问题。这些问题主要涉及慢性医学问题以及可能干扰幸存者生活质量的心理社会并发症。特定治疗可能导致严重感染、甲状腺、心血管、肺部、消化或性腺功能障碍。它还可能导致继发性恶性肿瘤，这被认为是最严重的并发症。由于绝大多数实现缓解的患者将保持无症状并能正常生活，长期随访应专注于预防和早期发现与治疗相关的并发症以及继发性恶性肿瘤。
