Valagussa P, Santoro A, Bonadonna G
Division of Medical Oncology, Istituto Nazionale Tumori, Milan, Italy.
Ann Oncol. 1992 Sep;3 Suppl 4:111-5. doi: 10.1093/annonc/3.suppl_4.s111.
Modern therapy of Hodgkin's disease has produced the expectation of long-term survival for most patients. However, in the process of achieving the current success, a price has been paid in unwanted, delayed side effects. Apart from second malignancies and gonadal impairment, other adverse consequences can be identified. This paper will briefly summarize recent findings related to thyroid, pulmonary and cardiac dysfunction. Attention to treatment regimens and careful follow-up may help to prevent or manage these complications, which are uncommonly life-threatening. The desire to refine the treatment of Hodgkin's disease must not result in a reduction of the overall chance of cure.
现代霍奇金淋巴瘤的治疗使大多数患者有望获得长期生存。然而，在取得当前成功的过程中，也付出了代价，出现了不良的、延迟的副作用。除了二次恶性肿瘤和性腺损伤外，还可发现其他不良后果。本文将简要总结近期与甲状腺、肺和心脏功能障碍相关的研究结果。关注治疗方案并进行仔细随访可能有助于预防或处理这些并发症，这些并发症一般不会危及生命。优化霍奇金淋巴瘤治疗方案的愿望绝不能导致总体治愈机会的降低。
