Rosenblatt K A, Thomas D B
Department of Community Health, Champaign, Illinois, USA.
Cancer Epidemiol Biomarkers Prev. 1996 Nov;5(11):933-5.
Possible relationships between tubal ligation and hysterectomy and epithelial ovarian cancer were assessed in data that were collected for a multinational hospital-based case-control study conducted between 1979 and 1988. Histologically confirmed incident cases (n = 393) were compared with controls (n = 2563) matched on age, hospital, and year of interview. A nonsignificant reduction in risk was observed for tubal ligation [odds ratio (OR), 0.72; 95% confidence interval (CI), 0.48-1.08] and hysterectomy (OR, 0.58; 95% CI, 0.26-1.27). There was no trend in risk with time since tubal ligation. The possible protective effect of tubal ligation was greatest in women of parity less than four. The apparent protective effect of tubal ligation was seen only for clear cell (OR, 0.32; 95% CI, 0.006-2.50) and endometrioid (OR, 0.20; 95% CI, 0.046-1.46) tumors, suggesting a hormonal mechanism for the observed associations.
在1979年至1988年进行的一项多国基于医院的病例对照研究收集的数据中，评估了输卵管结扎、子宫切除术与上皮性卵巢癌之间可能的关系。将组织学确诊的新发病例（n = 393）与在年龄、医院和访谈年份上匹配的对照组（n = 2563）进行比较。观察到输卵管结扎的风险有不显著降低[比值比（OR），0.72；95%置信区间（CI），0.48 - 1.08]，子宫切除术的风险也有不显著降低（OR，0.58；95% CI，0.26 - 1.27）。自输卵管结扎以来，风险没有随时间变化的趋势。输卵管结扎的可能保护作用在产次少于4次的女性中最为明显。输卵管结扎的明显保护作用仅在透明细胞癌（OR，0.32；95% CI，0.006 - 2.50）和子宫内膜样癌（OR，0.20；95% CI，0.046 - 1.46）中可见，提示所观察到的关联存在激素机制。
