Cornelison T L, Natarajan N, Piver M S, Mettlin C J
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Cancer Detect Prev. 1997;21(1):1-6.
To assess the relationship of tubal ligation and risk of ovarian carcinoma, we conducted a case-control, retrospective analysis of 300 ovarian carcinoma cases and 606 nonmalignant disease controls, seen between 1982 and 1988 at Roswell Park Cancer Institute, Buffalo, New York. Women who had a tubal ligation had reduced risk for the development of ovarian cancer. This relative risk was 0.52, with a 95% confidence interval 0.31 to 0.85 (p = 0.0076). Controls were matched by age. Multivariate analysis adjusted for socioeconomic level, marital status, parity, age at first pregnancy, menarche age, menopause age, irregular menses, breast-feeding duration, body habitus, and oral contraceptive use. Suggested explanations for this observation are offered.
为评估输卵管结扎与卵巢癌风险之间的关系，我们对1982年至1988年期间在纽约州布法罗市罗斯韦尔帕克癌症研究所就诊的300例卵巢癌病例和606例非恶性疾病对照进行了病例对照回顾性分析。进行过输卵管结扎的女性患卵巢癌的风险降低。相对风险为0.52，95%置信区间为0.31至0.85（p = 0.0076）。对照按年龄匹配。多因素分析对社会经济水平、婚姻状况、产次、初孕年龄、月经初潮年龄、绝经年龄、月经不规律、母乳喂养持续时间、体型和口服避孕药使用情况进行了校正。本文还对这一观察结果提出了解释。
