Ikeno K, Koike K, Fukuromoto T, Shimizu T, Nagatomo M, Komiyama A
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Early Hum Dev. 1996 Nov 21;46(3):229-37. doi: 10.1016/0378-3782(96)01766-5.
To examine whether perinatal complications induce the production of macrophage-colony stimulating factor (M-CSF), we have compared M-CSF levels in the cord blood between normal neonates and neonates with complications.
The M-CSF levels were determined by enzyme-linked immunosorbent assay (ELISA).
In 54 normal neonates, the M-CSF level was 1859 +/- 287 U/ml (mean +/- S.D.), being significantly higher than the serum M-CSF level in normal adults (697 +/- 132 U/ml). Compared with M-CSF levels in normal neonates, significantly higher levels were evidenced in neonates with perinatal complications including premature rupture of the membranes, neonatal asphyxia, meconium staining of the amniotic fluid and maternal anemia. However, no difference in M-CSF concentrations was observed irrespective of complication types; furthermore, the M-CSF level was highly correlated with the leukocyte counts in the neonates with complications, but not in normal neonates. Incidentally, CRP levels were within normal limits in most of these neonates,
M-CSF levels in the cord blood from neonates with premature rupture of the membranes, neonatal asphyxia, meconium staining of the amniotic fluid and maternal anemia were significantly higher than those in the cord blood sampled from normal neonates. The stress given to neonates may account for the higher M-CSF levels rather than infections.
为了研究围产期并发症是否会诱导巨噬细胞集落刺激因子（M-CSF）的产生，我们比较了正常新生儿和有并发症新生儿脐带血中的M-CSF水平。
采用酶联免疫吸附测定法（ELISA）测定M-CSF水平。
54例正常新生儿的M-CSF水平为1859±287 U/ml（平均值±标准差），显著高于正常成年人的血清M-CSF水平（697±132 U/ml）。与正常新生儿的M-CSF水平相比，有围产期并发症的新生儿，包括胎膜早破、新生儿窒息、羊水胎粪污染和母亲贫血，其M-CSF水平显著更高。然而，无论并发症类型如何，M-CSF浓度均无差异；此外，有并发症新生儿的M-CSF水平与白细胞计数高度相关，但正常新生儿则不然。顺便说一下，大多数这些新生儿的CRP水平都在正常范围内。
胎膜早破、新生儿窒息、羊水胎粪污染和母亲贫血的新生儿脐带血中的M-CSF水平显著高于正常新生儿脐带血中的水平。新生儿所承受的应激而非感染可能是M-CSF水平较高的原因。
