Black J B, Durigon E, Kite-Powell K, de Souza L, Curli S P, Afonso A M, Theobaldo M, Pellett P E
Centers for Disease Control and Prevention, Atlanta, Georgia.
Clin Infect Dis. 1996 Nov;23(5):1156-8. doi: 10.1093/clinids/23.5.1156.
We collected acute-phase and convalescent-phase serum samples from Brazilian patients who presented with exanthem of unknown origin and evaluated these samples by means of an immunoblot assay for seroconversion to human herpesvirus 6 (HIV-6) or human herpesvirus 7 (HIV-7). Measles or rubella had been clinically diagnosed in all these patients, but their sera were negative for antibodies to both measles virus and rubella virus. Twenty percent of the patients clearly seroconverted to HHV-6 after manifestation of the exanthem, and 8% seroconverted to HHV-7. All seroconversions to HHV-6 occurred in children aged < or = 5 years; a 41% frequency of seroconversion to HHV-6 was noted among children between 3 months and 23 months of age, whereas seroconversions to HHV-7 were detected during infancy and through adulthood. Our data indicate that primary infections due to HHV-6 or HHV-7 can be misdiagnosed as measles or rubella.
我们收集了来自巴西出现不明原因皮疹患者的急性期和恢复期血清样本，并通过免疫印迹法评估这些样本，以检测是否血清转化为人类疱疹病毒6型（HHV-6）或人类疱疹病毒7型（HHV-7）。所有这些患者临床上均诊断为麻疹或风疹，但他们的血清中麻疹病毒和风疹病毒抗体均为阴性。20%的患者在皮疹出现后血清明显转化为HHV-6，8%的患者血清转化为HHV-7。所有向HHV-6的血清转化均发生在年龄≤5岁的儿童中；在3个月至23个月大的儿童中，向HHV-6血清转化的频率为41%，而向HHV-7的血清转化在婴儿期至成年期均可检测到。我们的数据表明，HHV-6或HHV-7引起的原发性感染可能被误诊为麻疹或风疹。
