Cerinic M M, Generini S, Pignone A, Casale R
Institute of Internal Medicine IV, University of Florence, Italy.
Rheum Dis Clin North Am. 1996 Nov;22(4):879-92. doi: 10.1016/s0889-857x(05)70306-9.
The involvement of the nervous system in SSc is well recognized today. Different pathogenetic mechanisms are suggested that may alternatively explain the multiform appearance of the clinical spectrum (mononeuritis, mononeuritis multiplex, carpal tunnel syndrome, and so forth). It is now clear that the ANS is the earliest structure targeted by the disease in the gastrointestinal tract. The importance of this observation has not yet been adequately interpreted but may, together with the increasing evidence of the nervous system involvement in SSc, become a leading factor in understanding of the importance of the nervous system in the onset, development, and maintenance of the disease.
如今，神经系统在系统性硬化症（SSc）中的作用已得到充分认识。人们提出了不同的发病机制，这些机制可能交替解释临床谱的多种表现形式（单神经炎、多发性单神经炎、腕管综合征等）。现在很清楚，自主神经系统（ANS）是胃肠道中该疾病最早靶向的结构。这一观察结果的重要性尚未得到充分解读，但可能与越来越多的神经系统参与SSc的证据一起，成为理解神经系统在该疾病的发生、发展和维持中的重要性的主导因素。
