Brayman A A, Azadniv M, Cox C, Miller M W
Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, NY 14642, USA.
Ultrasound Med Biol. 1996;22(7):927-38. doi: 10.1016/0301-5629(96)00108-1.
The tested hypothesis was that ultrasound-induced hemolysis in blood supplemented with a microbubble contrast agent varies with ultrasound intensity and pulse duration. Human erythrocytes in autologous plasma containing 3.6% v:v Albunex microspheres were exposed to 1.07-MHz ultrasound pulses of 5 to 1000 mus at SPTP intensities of 0 to 1100 W/cm2. The dependence of hemolysis on the mechanical index (MI) value of the exposures was also examined. Ultrasound-induced hemolysis: (1) was evident at all pulse/intensity combinations; (2) increased generally with increasing pulse duration at constant intensity; and (3) increased with increasing MI at constant pulse duration. For pulses of 10 to 30 mus, ultrasound-induced hemolysis remained low (< or = 2%) at MI values < approximately 2 and increased sharply with further increase in MI; for 5-mus pulses, this abrupt increase in hemolysis was associated with a larger MI (approximately 3).
所验证的假设是，在添加了微泡造影剂的血液中，超声诱导的溶血会随超声强度和脉冲持续时间而变化。将含有3.6%（体积比）Albunex微球的自体血浆中的人红细胞暴露于0至1100 W/cm²的声压峰值 (SPTP) 强度下、持续时间为5至1000 μs的1.07-MHz超声脉冲。还研究了溶血对暴露的机械指数 (MI) 值的依赖性。超声诱导的溶血：(1) 在所有脉冲/强度组合下均明显；(2) 在强度恒定的情况下，通常随脉冲持续时间的增加而增加；(3) 在脉冲持续时间恒定的情况下，随MI的增加而增加。对于10至30 μs的脉冲，当MI值<约2时，超声诱导的溶血仍然较低（≤2%），并且随着MI的进一步增加而急剧增加；对于5 μs的脉冲，溶血的这种突然增加与更大的MI（约3）相关。
