Ashida T, Tsubaki K, Hazu S, Ishikawa H, Urase F, Horiuchi A
Third Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
Int J Hematol. 1996 Oct;64(3-4):279-81. doi: 10.1016/0925-5710(96)00490-2.
A 28-year old woman delivered a normal child at 85 months after bone marrow transplantation (BMT) for severe aplastic anemia (SAA). BMT was done after conditioning with cyclophosphamide (CY: 50 mg/kg/day for 4 days), anti-lymphocyte globulin (ALG: 50 mg/kg/day for 3 days) and total lymphoid irradiation (TLI: 5 Gy in a single fraction). Ovarian shielding was not done during irradiation. Six months after BMT, she gained normal menstruation spontaneously. Serum gonadotrophin levels were within the normal range, with an LH level of 34.6 mIU/ml (normal: 1-36 mIU/ml) and an FSH level of 13.4 mIU/ml (normal: 1-30 mIU/ml), at 38 months after BMT. She became pregnant 8 years after BMT and delivered a female child, who is now 3 years old and shows normal development.
一名28岁女性在因重型再生障碍性贫血（SAA）接受骨髓移植（BMT）85个月后产下一名正常婴儿。移植前的预处理方案包括环磷酰胺（CY：50mg/kg/天，共4天）、抗淋巴细胞球蛋白（ALG：50mg/kg/天，共3天）以及全身淋巴结照射（TLI：单次剂量5Gy）。照射期间未进行卵巢屏蔽。骨髓移植6个月后，她月经自然恢复正常。骨髓移植38个月时，血清促性腺激素水平在正常范围内，促黄体生成素（LH）水平为34.6mIU/ml（正常范围：1 - 36mIU/ml），促卵泡生成素（FSH）水平为13.4mIU/ml（正常范围：1 - 30mIU/ml）。她在骨髓移植8年后怀孕并产下一名女婴，现3岁，发育正常。
