Gören N, Woerdenbag H J, Bozok-Johansson C
TUBITAK, Marmara Research Center, Department of Chemistry, Gebze-Kocaeli, Turkey.
Planta Med. 1996 Oct;62(5):419-22. doi: 10.1055/s-2006-957930.
Ten sesquiterpene lactones and one sesquiterpene isolated from Tanacetum praeteritum subsp. praeteritum: 1 alpha, 6 alpha -dihydroxyisocostic acid methyl ester (2), 1 alpha-hydroxy-1-deoxoarglanine (3), douglanin (5), santamarin (6), reynosin (7), 1-epitatridin B (8), ludovicin A (10), armexin (12), armefolin (13), armexifolin (14), and 3 alpha-hydroxyreynosin (15) were tested against the human lung carcinoma cell line GLC4 and the colorectal cancer cell line COLO 320 as well as against the bacteria Bacillus subtilis, Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus, beta-hemolytic Streptococcus, and the yeast Candida albicans. In addition, two germacranolides tatridin A (16) and tamirin (17) were included in the study. All compounds showed cytotoxic activity (IC50 = 124 microM) but most of them were not effective in the antimicrobial tests.
从准噶尔菊蒿亚种准噶尔菊蒿中分离得到的10种倍半萜内酯和1种倍半萜：1α,6α -二羟基异波斯菊酸甲酯（2）、1α -羟基-1-脱氧阿兰宁（3）、道格拉宁（5）、山道年苦素（6）、雷诺辛（7）、1-表替里定B（8）、卢多维辛A（10）、阿尔梅辛（12）、阿尔梅福林（13）、阿尔梅西福林（14）以及3α -羟基雷诺辛（15），针对人肺癌细胞系GLC4和结肠癌细胞系COLO 320以及细菌枯草芽孢杆菌、金黄色葡萄球菌、奇异变形杆菌、大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、肠球菌、β -溶血性链球菌和酵母白色念珠菌进行了测试。此外，两种吉马烷型倍半萜内酯替里定A（16）和塔米林（17）也被纳入该研究。所有化合物均表现出细胞毒性活性（半数抑制浓度IC50 = 124微摩尔），但它们中的大多数在抗菌测试中无效。
