来自Eutypella sp. 1-15的新型12,8-桉烷内酯。
New 12,8-Eudesmanolides from Eutypella sp. 1-15.
作者信息
Wang Yuezhou, Wang Yue, Wu An-An, Zhang Lei, Hu Zhiyu, Huang Huiying, Xu Qingyan, Deng Xianming
机构信息
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.
State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, China.
出版信息
J Antibiot (Tokyo). 2017 Oct;70(10):1029-1032. doi: 10.1038/ja.2017.89. Epub 2017 Jul 19.
Four new 12,8-Eudesmanolides (1-4) and one known compound 5 named 13-Hydroxy-3,7(11)-eudesmadien-12,8-olide, were isolated from a mangrove rhizosphere-derived fungus Eutypella sp. 1-15. Their structures with absolute stereochemistry were determined by the comprehensive spectroscopic data, experimental and calculated ECD analysis. Compound 1 exhibited potent anticancer activity against JEKO-1 and HepG2 with IC values of 8.4 and 28.5 μM, respectively. Additionally, compound 1 also showed moderate antimicrobial activity.
从一种源自红树林根际的真菌 Eutypella sp. 1-15 中分离出了四种新的 12,8-桉叶烷型倍半萜内酯（1-4）以及一种名为 13-羟基-3,7(11)-桉叶二烯-12,8-内酯的已知化合物 5。通过综合光谱数据、实验性和计算性电子圆二色光谱（ECD）分析确定了它们具有绝对立体化学的结构。化合物 1 对 JEKO-1 和 HepG2 表现出强效抗癌活性，IC 值分别为 8.4 和 28.5 μM。此外，化合物 1 还显示出中等抗菌活性。
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