仓鼠中与克林霉素相关的结肠炎：万古霉素的保护作用。
Clindamycin-associated colitis in hamsters: protection with vancomycin.
作者信息
Bartlett J G, Onderdonk A B, Cisneros R L
出版信息
Gastroenterology. 1977 Oct;73(4 Pt 1):772-6.
PMID:892381
Abstract
Clindamycin and lincomycin produced a lethal enterocolitis in 65 of 67 Syrian hamsters. The administration of oral or parenteral vancomycin to recipients of clindamycin or lincomycin was uniformly protective in 49 patients. These results suggest that certain bacteria play a role in the pathogenesis of enterocolitis in this model.
摘要
克林霉素和林可霉素在67只叙利亚仓鼠中的65只引发了致死性小肠结肠炎。对接受克林霉素或林可霉素治疗的患者口服或肠胃外给予万古霉素均有保护作用，49例患者均受保护。这些结果表明，在该模型中某些细菌在小肠结肠炎的发病机制中起作用。
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