Feingold D S, Chen W C, Chou D L, Chang T W
Arch Dermatol. 1979 May;115(5):580-1.
Syrian hamsters are exquisitely sensitive to clindamycin; as little as 1 mg/kg of clindamycin given systemically causes a fatal colitis. Clindamycin and erythromycin were applied topically daily to the shaved backs of Syrian hamsters in a hydroalcoholic vehicle. A daily dose of 0.1 mg of clindamycin was lethal to more than half the hamsters and 1 mg to all the animals. The antibiotic-associated toxin from Clostridium difficile was present in their cecal material. Based on body surface areas and estimated usual volumes applied, the lethal dose in hamsters is not dissimilar to that given humans for acne. Oral tetracycline therapy protected the animals from clindamycin toxicity, but the animals died three days after stopping tetracycline if topical clindamycin applications were continued.
叙利亚仓鼠对克林霉素极为敏感；全身给予低至1毫克/千克的克林霉素就会引发致命性结肠炎。将克林霉素和红霉素每日局部应用于用酒精水溶液剃毛的叙利亚仓鼠背部。每日剂量为0.1毫克的克林霉素对半数以上的仓鼠致死，1毫克则对所有动物致死。其盲肠物质中存在艰难梭菌产生的与抗生素相关的毒素。根据体表面积和估计的常用涂抹量，仓鼠的致死剂量与用于治疗痤疮的人类剂量并无不同。口服四环素疗法可保护动物免受克林霉素毒性影响，但如果继续局部应用克林霉素，动物在停用四环素三天后死亡。
