Kurinnyĭ A I, Pilinskaia M A
Genetika. 1977;13(2):337-9.
The cytogenetic action of three phosphoorganic pesticides, imidan, dipterex and gardona, in cultured human lymphocytes is studied. It is found that all the sunstances induce the signficant increase in the frequency of metaphases with chromosomes aberrations as compared with the control level. Maximal effects in vitro qere 6,0; 4,8 and 4,0% of aberrant cells for imidan, dipterex and gardona respectively. All investigated substances had a weak mutagenic activity in human lymphocyte culture.
研究了三种有机磷农药亚胺硫磷、敌百虫和毒虫畏在培养的人淋巴细胞中的细胞遗传学作用。发现与对照水平相比，所有这些物质均能使染色体畸变中期相的频率显著增加。亚胺硫磷、敌百虫和毒虫畏在体外的最大效应分别为异常细胞的6.0%、4.8%和4.0%。所有研究的物质在人淋巴细胞培养中均具有较弱的诱变活性。
