Martson L V, Voronina V M
Environ Health Perspect. 1976 Feb;13:121-5. doi: 10.1289/ehp.7613121.
Experiments conducted on pregnant Wistar rats show that chlorophos (Dipterex) has embroyotoxic and teratogenic effects after oral introduction in a 80 mg/kg dose during a critical period of embryogenesis. Embryotoxic and teratogenic effects are absent during the introduction of 8 mg/kg of the pesticide. The oral introduction of phthalophos (Imidan) in a 30 mg/kg dose once on day 9 of pregnancy and the introduction of a 1.5 mg/kg dose daily throughout the course of pregnancy caused increased postimplantation mortality of embryos. A dose of 30 mg/kg of phthalophos on day 9 or day 13 of pregnancy causes developmental abnormalities, including hyponathia and hydrocephaly. A 0.06 mg/kg phthalophos dose does not affect the course of embryogenesis in white rats. Thus the organophosphate pesticides Dipterex and Imidan exhibit embryotoxic and teratogenic effects at doses which significantly exceed the acutal amounts of the pesticide that can enter the human organism.
对怀孕的Wistar大鼠进行的实验表明，在胚胎发育的关键时期，以80毫克/千克的剂量口服毒死蜱（敌百虫）会产生胚胎毒性和致畸作用。在引入8毫克/千克的农药时，没有胚胎毒性和致畸作用。在怀孕第9天以30毫克/千克的剂量口服酞酸酯（亚胺硫磷）一次，并在整个怀孕期间每天引入1.5毫克/千克的剂量，会导致胚胎着床后死亡率增加。在怀孕第9天或第13天给予30毫克/千克的酞酸酯剂量会导致发育异常，包括低钠血症和脑积水。0.06毫克/千克的酞酸酯剂量不会影响白鼠的胚胎发育过程。因此，有机磷农药敌百虫和亚胺硫磷在显著超过可能进入人体的农药实际量的剂量下会表现出胚胎毒性和致畸作用。
