Nishiyama N, Chu P J, Saito H
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Biol Pharm Bull. 1996 Mar;19(3):388-93. doi: 10.1248/bpb.19.388.
The effect of an herbal prescription, S-113m, consisting of biota, ginseng and schizandra, on learning and memory performance was studied in the senescence accelerated mouse (SAM). A solid diet containing 1% (w/w) S-113m was given to SAM from 1 month of age. A behavioral experiment, started 4 or 9 months later, revealed prominent learning impairment in SAMP8, a senescence accelerated-prone mouse. Chronic ingestion of S-113m improved the memory retention disorder of SAMP8 in a passive avoidance test and increased the conditioned avoidance rate in a lever-press test at the age of 10 months. The preparation also facilitated the memory retention deficit in the passive avoidance test in 10-month-old SAMR1, a senescent resistant substrain. These results raise the possibility that S-113m might be useful for treating physiological aging and age-related memory deficits in human.
研究了由侧柏、人参和五味子组成的草药方剂S-113m对衰老加速小鼠（SAM）学习和记忆能力的影响。从1月龄开始，给SAM喂食含1%（w/w）S-113m的固体饲料。4个月或9个月后开始的行为实验显示，衰老加速易感性小鼠SAMP8存在明显的学习障碍。长期摄入S-113m可改善SAMP8在被动回避试验中的记忆保持障碍，并在10月龄时提高杠杆按压试验中的条件回避率。该制剂还改善了10月龄抗衰老亚系SAMR1在被动回避试验中的记忆保持缺陷。这些结果提示，S-113m可能对治疗人类生理性衰老和与年龄相关的记忆缺陷有用。
