Nishiyama N, Zhou Y, Saito H
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Biol Pharm Bull. 1994 Nov;17(11):1481-4. doi: 10.1248/bpb.17.1481.
DX-9386 is a traditional Chinese prescription consisting of ginseng, polygala, acorus and hoelen. The effect of chronic oral treatment with this preparation on learning behaviors and lipid peroxide concentration was studied in senescence accelerated mouse (SAM). SAM P8, a senescence prone of SAM, and SAM R1, a senescence resistant substrain of SAM, were started on a diet containing 1% of DX-9386 from the age of 2 months. All the experiments were performed at the age of 10 months. The prescription ameliorated the memory disorders of SAM P8, as evaluated in a step down test as well as a spatial memory test. The preparation, however, did not affect the learning behaviors in SAM R1. DX-9386 reduced the elevated levels of lipid peroxide in the serum and liver of SAM P8, while it did not alter that in SAM R1. These results suggested that DX-9386 slowed the aging process of SAM P8 in terms of learning behaviors and lipid peroxidation.
DX - 9386是一种由人参、远志、菖蒲和茯苓组成的中药方剂。研究了该制剂长期口服对快速老化小鼠（SAM）学习行为和脂质过氧化物浓度的影响。SAM P8是SAM的易老化品系，SAM R1是SAM的抗老化亚品系，从2月龄开始给予含1% DX - 9386的饮食。所有实验均在10月龄时进行。在跳台试验和空间记忆试验中评估，该方剂改善了SAM P8的记忆障碍。然而，该制剂对SAM R1的学习行为没有影响。DX - 9386降低了SAM P8血清和肝脏中升高的脂质过氧化物水平，而对SAM R1没有改变。这些结果表明，DX - 9386在学习行为和脂质过氧化方面减缓了SAM P8的衰老过程。
