Moriguchi T, Takashina K, Chu P J, Saito H, Nishiyama N
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Biol Pharm Bull. 1994 Dec;17(12):1589-94. doi: 10.1248/bpb.17.1589.
The effects of aged garlic extract (AGE) on longevity and learning and memory performances were studied in the senescence accelerated mouse (SAM). A solid diet containing 2% (w/w) AGE was given to SAM from 2 months of age. The survival ratio of SAM P8, senescence accelerated animals, treated with AGE was significantly higher than that of untreated controls. AGE, however, did not affect the life span of SAM R1, a senescence-resistant strain. AGE had no effect on body weight and motor activity. In the passive and conditioned avoidance tests, AGE markably improved a memory acquisition process in the step-down and shuttle-box tests, and also a retention process in the step-through and step-down tests in SAM P8. The beneficial effects of AGE were observed in a memory retention process in the step-down test and in an acquisition stage in lever-press test in SAM R1. These results suggest the possibility that AGE might be useful for treating physiological aging and age-related memory deficits in humans.
在衰老加速小鼠（SAM）中研究了 aged garlic extract（AGE，老化大蒜提取物）对寿命以及学习和记忆能力的影响。从2月龄开始给SAM喂食含2%（w/w）AGE的固体饲料。用AGE处理的衰老加速动物SAM P8的存活率显著高于未处理的对照组。然而，AGE并不影响抗衰老品系SAM R1的寿命。AGE对体重和运动活动没有影响。在被动和条件性回避试验中，AGE显著改善了SAM P8在跳台和穿梭箱试验中的记忆获取过程，以及在穿通和跳台试验中的记忆保持过程。在SAM R1的跳台试验记忆保持过程和杠杆按压试验的获取阶段观察到了AGE的有益作用。这些结果提示AGE可能对治疗人类的生理性衰老和与年龄相关的记忆缺陷有用。
