Banerjee G, Ayyagari A, Prasad K N, Dhole T N, Singh S K
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.
Indian J Med Res. 1996 Jan;103:58-61.
A total of 151 Enterobacter cloacae strains isolated from clinical samples (n = 139) and the hospital environment (n = 12) at a tertiary care hospital in northern India during January to October 1993, were analysed. The maximum isolations were during May (n = 24), June (n = 23) and July (n = 22). Urinary tract infection (n = 56) was the most common complication of E. cloacea infection followed by wound infection (42), respiratory tract infection (23) and bacteraemia/septicaemia (18). The frequency of resistance to different drugs was ampicillin 77.4 per cent, cotrimoxazole 79.5 per cent, gentamicin 57.5 per cent, cefotaxime 47 per cent and ofloxacin 36 per cent. Sixty three (41.7%) strains exhibited resistance to multiple drugs. Environmental isolates from bed, hospital diet, hand swab and water from a leaking drain pipe in a ward showed the same resistance pattern. A single index strain could not be identified using phage and biotyping, indicating that a variety of strains were responsible for the nosocomial infection. Adoption of strict aseptic measures and repair of the pipe brought down the infection rate.
对1993年1月至10月期间在印度北部一家三级护理医院从临床样本（n = 139）和医院环境（n = 12）中分离出的151株阴沟肠杆菌菌株进行了分析。分离数量最多的月份是5月（n = 24）、6月（n = 23）和7月（n = 22）。尿路感染（n = 56）是阴沟肠杆菌感染最常见的并发症，其次是伤口感染（42例）、呼吸道感染（23例）和菌血症/败血症（18例）。对不同药物的耐药频率分别为：氨苄西林77.4%、复方新诺明79.5%、庆大霉素57.5%、头孢噻肟47%、氧氟沙星36%。63株（41.7%）菌株表现出对多种药物耐药。从病房的病床、医院饮食、手拭子以及一根漏水排水管中的水分离出的环境菌株显示出相同的耐药模式。使用噬菌体和生物分型无法鉴定出单一的指示菌株，这表明多种菌株导致了医院感染。采取严格的无菌措施并修复管道后，感染率下降。
