Moji H, Murata T, Morinobu T, Manago M, Tamai H, Okamoto R, Mino M, Fujimura M, Takeuchi T
Department of Pediatrics, Osaka Medical College, Takatsuki, Japan.
J Nutr Sci Vitaminol (Tokyo). 1995 Dec;41(6):595-606. doi: 10.3177/jnsv.41.595.
In neonatal medicine, it is thought that retinol is useful for preventing CLD and for fetal development. However, beta-carotene had other vitamin A precursors have not been studied in neonates with CLD or others disorders. Cord blood of neonates including ELBW and VLBW infants was assayed for plasma levels of retinol, RBP, beta-carotene and cryptoxanthin. Plasma beta-carotene levels in ELBW and VLBW were lower than that in term infants, but plasma cryptoxanthin levels in ELBW and VLBW were about the same as in term infants. Plasma retinol and RBP levels showed almost same levels during 23-41 gestational weeks. Maternal smoking reduced plasma beta-carotene but not cryptoxanthin, retinol, or RBP levels. IUGR was associated with increased cryptoxanthin levels in cord blood. Serious neonatal diseases, including CLD and ROP manifested no significant effects on the cord blood vitamin levels. Thus, the occurrence of these diseases at birth could not be predicted by examination of vitamin levels in cord blood.
在新生儿医学中，人们认为视黄醇对预防慢性肺疾病（CLD）和胎儿发育有用。然而，β-胡萝卜素及其他维生素A前体在患有CLD或其他疾病的新生儿中尚未得到研究。对包括极低出生体重（ELBW）和超低出生体重（VLBW）婴儿在内的新生儿脐带血进行了视黄醇、视黄醇结合蛋白（RBP）、β-胡萝卜素和隐黄质血浆水平的检测。ELBW和VLBW婴儿的血浆β-胡萝卜素水平低于足月儿，但ELBW和VLBW婴儿的血浆隐黄质水平与足月儿大致相同。在孕23 - 41周期间，血浆视黄醇和RBP水平显示出几乎相同的水平。母亲吸烟会降低血浆β-胡萝卜素水平，但不会降低隐黄质、视黄醇或RBP水平。宫内生长受限（IUGR）与脐带血中隐黄质水平升高有关。包括CLD和视网膜病变（ROP）在内的严重新生儿疾病对脐带血维生素水平无显著影响。因此，无法通过检测脐带血中的维生素水平来预测这些疾病在出生时的发生情况。
