人肝脏己糖胺酶A和B对神经节苷脂GM2和GA2的特异性。采用特异性洗脱通过亲和色谱法纯化这些酶。 - Suppr

Suppr

超能文献

Specificity of human liver hexosaminidases A and B against glycosphingolipids GM2 and GA2. Purification of the enzymes by affinity chromatography employing specific elution.

作者信息

Sandhoff K, Conzelmann E, Nehrkorn H

出版信息

Hoppe Seylers Z Physiol Chem. 1977 Jul;358(7):779-87. doi: 10.1515/bchm2.1977.358.2.779.

DOI:10.1515/bchm2.1977.358.2.779

PMID:892710

Abstract

摘要

相似文献

Specificity of human liver hexosaminidases A and B against glycosphingolipids GM2 and GA2. Purification of the enzymes by affinity chromatography employing specific elution.人肝脏己糖胺酶A和B对神经节苷脂GM2和GA2的特异性。采用特异性洗脱通过亲和色谱法纯化这些酶。

Hoppe Seylers Z Physiol Chem. 1977 Jul;358(7):779-87. doi: 10.1515/bchm2.1977.358.2.779.

The specificity of human N-acetyl-beta-D-hexosaminidases towards glycosphincolipids is determined by an activator protein.人N-乙酰-β-D-己糖胺酶对糖鞘脂的特异性由一种激活蛋白决定。

Adv Exp Med Biol. 1980;125:295-306. doi: 10.1007/978-1-4684-7844-0_27.

Purification of human hexosaminidases A and B by affinity chromatography.

FEBS Lett. 1974 Sep 1;45(1):276-81. doi: 10.1016/0014-5793(74)80861-6.

Purification and characterization of an activator protein for the degradation of glycolipids GM2 and GA2 by hexosaminidase A.己糖胺酶A降解糖脂GM2和GA2的激活蛋白的纯化与特性分析

Hoppe Seylers Z Physiol Chem. 1979 Dec;360(12):1837-49. doi: 10.1515/bchm2.1979.360.2.1837.

Purification and some properties of liver and brain beta-N-acetyl-hexosaminidase S.肝脏和脑β-N-乙酰己糖胺酶S的纯化及某些性质

Biochim Biophys Acta. 1979 Jan 12;566(1):80-7. doi: 10.1016/0005-2744(79)90251-1.

Characterization of an activating factor required for hydrolysis of Gm2 ganglioside catalyzed by hexosaminidase A.己糖胺酶A催化的GM2神经节苷脂水解所需激活因子的特性分析。

Can J Biochem. 1977 Apr;55(4):315-24. doi: 10.1139/o77-044.

Substrate specificities of alpha-N-acetylgalactosaminidases I and II from squid liver.

Chem Pharm Bull (Tokyo). 1988 Oct;36(10):4000-7. doi: 10.1248/cpb.36.4000.

alpha-N-Acetylgalactosaminidase from squid liver: purification and characterization of two enzymes.

J Biochem. 1984 Apr;95(4):959-70. doi: 10.1093/oxfordjournals.jbchem.a134723.

Purification and separation of A and B forms of N-acetyl- -D-hexosaminidase from human aorta.从人主动脉中纯化和分离N-乙酰-β-D-己糖胺酶的A和B形式

Prep Biochem. 1973;3(3):221-41. doi: 10.1080/00327487308061508.

Immunological properties of N-acetyl-beta-D-glucosaminidase of normal human liver and of GM2-gangliosidosis liver.正常人肝脏及GM2神经节苷脂贮积症肝脏中N-乙酰-β-D-葡萄糖苷酶的免疫学特性

Biochem J. 1973 Jan;131(1):91-6. doi: 10.1042/bj1310091.

引用本文的文献

Microglia-neuron crosstalk through Hex-GM2-MGL2 maintains brain homeostasis.通过己糖-GM2-巨噬细胞半乳糖凝集素2的小胶质细胞-神经元串扰维持脑内稳态。

Nature. 2025 Aug 6. doi: 10.1038/s41586-025-09477-y.

Secondary ganglioside GM2 accumulation in mucopolysaccharidoses.黏多糖贮积症中继发性神经节苷脂GM2蓄积

Mol Genet Metab Rep. 2021 Aug 12;28:100789. doi: 10.1016/j.ymgmr.2021.100789. eCollection 2021 Sep.

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles.膜脂及其降解产物控制溶酶体腔内囊泡中的 GM2 分解代谢。

J Lipid Res. 2019 Jun;60(6):1099-1111. doi: 10.1194/jlr.M092551. Epub 2019 Apr 15.

Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.膜脂调节神经节苷脂GM2分解代谢及GM2激活蛋白活性。

J Lipid Res. 2015 Sep;56(9):1747-61. doi: 10.1194/jlr.M061036. Epub 2015 Jul 14.

Hexosaminidase assays.己糖胺酶测定。

Glycoconj J. 2009 Nov;26(8):945-52. doi: 10.1007/s10719-008-9137-5.

Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.人β-己糖胺酶B的晶体结构：理解桑德霍夫病和泰-萨克斯病的分子基础

J Mol Biol. 2003 Apr 11;327(5):1093-109. doi: 10.1016/s0022-2836(03)00216-x.

A single site in human beta-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside.人β-己糖胺酶A中的一个位点可同时结合己糖胺上的两个6-硫酸基团和GM2神经节苷脂的唾液酸部分。

Biochim Biophys Acta. 2003 Jan 20;1637(1):113-8. doi: 10.1016/s0925-4439(02)00221-1.

[Lipid-protein interactions: mechanisms of enzymatic glycolipid catabolism and their genetic restrictive escapes].[脂质-蛋白质相互作用：酶促糖脂分解代谢机制及其遗传限制逃逸]

Naturwissenschaften. 1980 Sep;67(9):431-41. doi: 10.1007/BF00405636.

Ganglioside GM2 N-acetyl-beta-D-galactosaminidase activity in cultured fibroblasts of late-infantile and adult GM2 gangliosidosis patients and of healthy probands with low hexosaminidase level.晚期婴儿型和成人型GM2神经节苷脂沉积症患者以及己糖胺酶水平较低的健康先证者的培养成纤维细胞中的神经节苷脂GM2 N-乙酰-β-D-半乳糖苷酶活性。

Am J Hum Genet. 1983 Sep;35(5):900-13.

Mucolipidosis III beta-N-acetyl-D-hexosaminidase A. Purification and properties.黏脂贮积症III型β-N-乙酰-D-己糖胺酶A。纯化及性质

Biochem J. 1982 Dec 1;207(3):421-8. doi: 10.1042/bj2070421.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验