Niścigorska J, Boroń-Kaczmarska A
Katedra i Klinika Chorób Zakaźnych PAM w Szczecinie.
Przegl Epidemiol. 1996;50(3):281-6.
In the period of 1989-1995 seven patients with amebic liver abscess were observed in Clinic of Infectious Diseases of Pomeranian Medical School in Szczecin. The diagnosis has been made on the base of epidemiological data, presence of intrahepatic defect by a scanning procedure of liver (ultrasonography, CT, scintigraphy) and positive serologic test for amebiasis. All patients were male of Polish nationality, 29-57 years old, who became ill after travel to Africa or India. Intestinal amebiasis was present only in two cases. Five patients had acute onset of disease and two chronic. The most common complaints included fever, abdominal pain, anorexia. A cough, chest pain, diarrhea or weight lose were less common. At physical examination paleness of skin, subjaundice, abdominal tenderness, hepatomegaly and sometimes pleural effusion have been observed. Laboratory tests revealed high RBS, leucocytosis and mild anemia. Slightly higher serum level of bilirubin, alkaline phosphatase were transient. Trophozoits of Entamoeba histolytica have been found in stool specimens of one only patient. Amebic antibodies tested with indirect hemagglutination (IHA) were present in all cases. Visual technics have shown abscess of 3 to 9 cm in diameter located at right liver lobe. Six patients have been treated with both chemotherapy (metronidazole or/and dehydroemetine) and "skin needle" aspiration. In two cases recrudescence of abscess has been observed after one and three years respectively. These two patients have been undergone second course of treatment with using not only needle aspiration and metronidazole/dehydroemetine but luminal agents as well.
1989年至1995年期间,什切青的波美拉尼亚医学院传染病诊所观察到7例阿米巴肝脓肿患者。诊断依据是流行病学数据、肝脏扫描检查(超声、CT、闪烁扫描)发现肝内缺损以及阿米巴病血清学检测呈阳性。所有患者均为波兰男性,年龄在29至57岁之间,在前往非洲或印度后患病。仅2例存在肠道阿米巴病。5例患者疾病急性发作,2例为慢性发作。最常见的症状包括发热、腹痛、厌食。咳嗽、胸痛、腹泻或体重减轻则较少见。体格检查发现皮肤苍白、亚黄疸、腹部压痛、肝肿大,有时还有胸腔积液。实验室检查显示红细胞沉降率高、白细胞增多和轻度贫血。血清胆红素、碱性磷酸酶水平略高,呈一过性。仅在1例患者的粪便标本中发现溶组织内阿米巴滋养体。所有病例间接血凝试验(IHA)检测的阿米巴抗体均呈阳性。影像学检查显示直径3至9厘米的脓肿位于肝右叶。6例患者接受了化疗(甲硝唑或/和去氢依米丁)及“皮肤针”穿刺抽吸治疗。2例患者分别在1年和3年后出现脓肿复发。这2例患者接受了第二个疗程的治疗,不仅采用了穿刺抽吸和甲硝唑/去氢依米丁治疗,还使用了肠内药物。