Orlova E V, Popovkin N N, Siniukhin V N, Stetsiuk E A
Urol Nefrol (Mosk). 1996 Jul-Aug(4):17-9.
The model has been designed by the authors to prevent complications as a result of redistribution of liquid between cellular and extracellular spaces arising in the patient's body in the course of hemodialysis. Because movements of the liquid between the spaces depends on the osmolality gradient, two principal systems were identified: body water system and system of osmotically active substances. The latter incorporates sodium and potassium salts and urea. The model is based on 6 differential equations. The least squares method derived individual parameters of the model. Using the model, the physician can regulate to optimal the regimen of hemodialysis: blood flow rate, speed of ultrafiltration, concentration of sodium and potassium in dialysate.
作者设计该模型是为了预防在血液透析过程中患者体内细胞内和细胞外空间之间液体重新分布所导致的并发症。由于这些空间之间的液体移动取决于渗透压梯度，因此确定了两个主要系统：身体水系统和渗透活性物质系统。后者包含钠盐、钾盐和尿素。该模型基于6个微分方程。最小二乘法得出了模型的各个参数。利用该模型，医生可以将血液透析方案调节至最佳状态：血流量、超滤速度、透析液中钠和钾的浓度。
