de Petriconi R, Kleinschmidt K, Flohr P, Paiss T, Hautmann R
Urologische Universitätsklinik Ulm.
Urologe A. 1996 Jul;35(4):284-90.
Orthotopic reconstruction to the native urethra has revolutionized urinary diversion, allowing patients to void per the urethra. This form of urinary diversion was initially performed solely in male patients after cystectomy. More recently, however, with a better understanding of the female continence mechanism, including the urethral/vaginal support mechanism, and the ability to select appropriate female candidates properly for this type of surgery, orthotopic reconstruction has become a viable option in women. Since November 1986, 24 women aged 53 years (range 17-76) have undergone orthotopic reconstruction using the ileal neobladder. Indications for cystectomy included transitional cell carcinoma of the bladder (8), fibrotic radiated bladder (4), interstitial cystitis (5), tuberculotic bladder (2), urge incontinence (2), neurogenic fibrotic bladder (2), and fibrotic bladder of unknown etiology (1). Nineteen patients are available with a median follow-up of 48 months (range 3 to 109 months). There were no perioperative deaths, with few early and late complications. Two women previously irradiated developed a neovesicovaginal fistula and had to be diverted by an ileal loop. Three patients from the far East are no longer available for follow-up. Ten years of experience with 24 patients have led to a nerve- and urethral-support-sparing cystectomy technique with the ileal neobladder anastomosed to the proximal urethra. However, even then, retention in 20% of the patients rather than the expected incontinence is the critical issue. Incontinence has never been a problem. The advent of orthotopic lower urinary reconstruction in women is a major achievement in the evolution of urinary diversion. With our increasing understanding of the continence mechanism in women and with increasing evidence that the female urethra can be safely preserved after cystectomy, orthotopic lower urinary tract reconstruction by the ileal neobladder can now be offered safely not only to males, but also to female patients undergoing cystectomy, and the functional results are superb.
原位重建至原生尿道彻底改变了尿流改道方式,使患者能够经尿道排尿。这种尿流改道形式最初仅在男性膀胱切除术后进行。然而,最近随着对女性控尿机制(包括尿道/阴道支撑机制)有了更深入的了解,以及能够为这类手术正确挑选合适的女性患者,原位重建已成为女性可行的选择。自1986年11月以来,24名年龄在53岁(范围17 - 76岁)的女性接受了使用回肠新膀胱的原位重建手术。膀胱切除的适应证包括膀胱移行细胞癌(8例)、放射性纤维化膀胱(4例)、间质性膀胱炎(5例)、结核性膀胱(2例)、急迫性尿失禁(2例)、神经源性纤维化膀胱(2例)以及病因不明的纤维化膀胱(1例)。19名患者可进行随访,中位随访时间为48个月(范围3至109个月)。围手术期无死亡病例,早期和晚期并发症较少。两名曾接受放疗的女性出现了新膀胱阴道瘘,不得不通过回肠袢进行尿流改道。3名来自远东地区的患者无法再进行随访。对24例患者的10年经验总结出了一种保留神经和尿道支撑的膀胱切除技术,即将回肠新膀胱与近端尿道吻合。然而,即便如此,20%的患者出现尿潴留而非预期的尿失禁仍是关键问题。尿失禁从未成为一个问题。女性原位下尿路重建的出现是尿流改道发展历程中的一项重大成就。随着我们对女性控尿机制的理解不断加深,以及越来越多的证据表明膀胱切除术后女性尿道可安全保留,现在不仅男性,接受膀胱切除术的女性患者也可安全地接受回肠新膀胱原位下尿路重建,且功能效果极佳。