油成分对不同大鼠品系中佐剂诱导的关节炎以及对纯化蛋白衍生物和肽聚糖的迟发型超敏反应的影响。
Effect of oil composition on both adjuvant-induced arthritis and delayed hypersensitivity to purified protein derivative and peptidoglycans in various rat strains.
作者信息
Kohashi O, Pearson M, Beck F J, Alexander M
出版信息
Infect Immun. 1977 Aug;17(2):244-9. doi: 10.1128/iai.17.2.244-249.1977.
We confirmed that, when immunized with a conventional complete Freund adjuvant (water in oil), Lewis rats were highly susceptible to adjuvant arthritis, Fisher rats were less susceptible, and Buffalo rats were much less susceptible. However, mycobacterial delipidated cells in squalane (squalane-type adjuvant) produced severe arthritis with almost 100% incidence even in the less susceptible rat strains except for Buffalo rats. With regard to an immune response, Freund complete adjuvant induced strong delayed hypersensitivity to purified protein derivative (PPD) and peptidoglycan (PG) in all rat strains used, Whereas the squalane-type adjuvant induced these hypersensitivities only in Lewis and Buffalo rats, but not in Fisher and Brown Norway rats. No correlation was found between development of arthritis and delayed hypersensitivity to either PPD or PG, or both. It seems that PPD hypersensitivity may be inherited differently from PG hypersensitivity.
我们证实，用传统的完全弗氏佐剂（油包水）免疫时，Lewis大鼠对佐剂性关节炎高度易感，Fisher大鼠较不易感，而布法罗大鼠则极不易感。然而，角鲨烷中的分枝杆菌脱脂细胞（角鲨烷型佐剂）即使在除布法罗大鼠外较不易感的大鼠品系中也会产生严重关节炎，发病率几乎达100%。关于免疫反应，弗氏完全佐剂在所有使用的大鼠品系中均诱导出对纯化蛋白衍生物（PPD）和肽聚糖（PG）的强烈迟发型超敏反应，而角鲨烷型佐剂仅在Lewis大鼠和布法罗大鼠中诱导出这些超敏反应，在Fisher大鼠和棕色挪威大鼠中则未诱导出。未发现关节炎的发生与对PPD或PG或两者的迟发型超敏反应之间存在相关性。似乎PPD超敏反应的遗传方式可能与PG超敏反应不同。
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