Abdulkadyrov K M, Bessmel'tsev S S, Rukavitsyn O A, Shilova E R, Rugal' V I
Arkh Patol. 1996 Jan-Feb;58(1):25-8.
Stromal structures of the bone marrow in 22 patients with aplastic anemia (AA) were studied histophotometrically. A significant increase of the fat tissue volume and a decrease of hematopoietic tissue volume were observed. Bone tissue volume was significantly increased in 81.8% of patients, the number of endosteal cells was increased in all the patients and that of reticular cells in one third of them. The conclusion is made that hematopoietic microenvironment of the bone is not a determining factor in the majority of AA patients. Excessive bone formation might be one of the mechanisms of aplasia development.
对22例再生障碍性贫血（AA）患者的骨髓基质结构进行了组织光度学研究。观察到脂肪组织体积显著增加，造血组织体积减少。81.8%的患者骨组织体积显著增加，所有患者的骨内膜细胞数量均增加，三分之一患者的网状细胞数量增加。得出的结论是，在大多数AA患者中，骨髓造血微环境不是决定性因素。骨形成过多可能是发育不全发生的机制之一。
