脂质血症效应作为氯喹视网膜毒性的一种表现。
Lipidemic effect as a manifestation of chloroquine retinotoxicity.
作者信息
Gaafar K M, Abdel-Khalek L R, el-Sayed N K, Ramadan G A
机构信息
Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt.
出版信息
Arzneimittelforschung. 1995 Nov;45(11):1231-5.
The effect of long-term treatment of chloroquine (CAS 54-05-7) (20 mg/kg body weight) on serum lipid components and its relation to to the retinotoxic effect was studied in albino rats. Chloroquine was found to form lamellar lysosome-like structures within the photoreceptive layer, as well as the pigment epithelium and neurooretinal layers. Biochemically, hypolipidemia in the serum was observed mainly due to the decrease in phospholipid portion. It was hypothesized that due to the inhibition of the degradation process in the defective lysosomes, the retinal cells were denied the re-use of their own phospholipids, and thereby resort to their uptake from the serum.
在白化大鼠中研究了长期使用氯喹（CAS 54-05-7）（20毫克/千克体重）对血清脂质成分的影响及其与视网膜毒性作用的关系。发现氯喹在光感受层以及色素上皮和神经视网膜层内形成板层状溶酶体样结构。生化方面，血清中出现低脂血症主要是由于磷脂部分减少。据推测，由于缺陷溶酶体中降解过程受到抑制，视网膜细胞无法再利用自身的磷脂，从而只能从血清中摄取。
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