Sato M, Kodama N, Sasaki T, Ohta M
Department of Neurosurgery, Fukushima Medical School, Japan.
J Neurosurg. 1996 Dec;85(6):1122-6. doi: 10.3171/jns.1996.85.6.1122.
Olfactory evoked potentials (OEPs), obtained by electrical stimulation of the olfactory mucosa, were recorded in dogs and humans to develop an objective method for evaluating olfactory functions. In dogs, OEPs were recorded from the olfactory tract and the scalp. The latency of the first negative peak was approximately 40 msec. A response was not obtained after stimulation of the nasal mucosa and disappeared after sectioning of the olfactory nerve. With increasing frequencies of repetitive stimulation, the amplitude was reduced, suggesting that the response was synaptically mediated. These results demonstrate that evoked potentials from the olfactory tract and the scalp following electrical stimulation of the olfactory mucosa originate specifically from the olfactory system. In humans, a stimulating electrode with a soft catheter was fixed on the olfactory mucosa. The OEPs from the olfactory tract, recorded with a negative peak of approximately 27 msec, had similar characteristics to OEPs found in dogs. The OEPs from the olfactory tract in humans also originate specifically from the olfactory system. The authors postulate that OEPs obtained by electrical stimulation of the olfactory mucosa may prove useful for intraoperative monitoring of olfactory functions.
通过电刺激嗅黏膜获得嗅觉诱发电位（OEPs），在犬类和人类中进行记录，以开发一种评估嗅觉功能的客观方法。在犬类中，从嗅束和头皮记录OEPs。第一个负峰的潜伏期约为40毫秒。刺激鼻黏膜后未获得反应，切断嗅神经后反应消失。随着重复刺激频率的增加，振幅降低，表明该反应是由突触介导的。这些结果表明，电刺激嗅黏膜后从嗅束和头皮记录到的诱发电位特异性地起源于嗅觉系统。在人类中，将带有软导管的刺激电极固定在嗅黏膜上。从嗅束记录到的OEPs，其负峰约为27毫秒，具有与在犬类中发现的OEPs相似的特征。人类嗅束的OEPs也特异性地起源于嗅觉系统。作者推测，通过电刺激嗅黏膜获得的OEPs可能被证明对嗅觉功能的术中监测有用。
