Ten Kate L P
Int J Epidemiol. 1977 Mar;6(1):23-34. doi: 10.1093/ije/6.1.23.
In the Netherlands a retrospective study of the prevalence of cystic fibrosis (CF) at birth has been performed by means of an inquiry set up among 815 medical specialists (paediatricians, lung specialists and pathologists) and by analysis of hospital admission data, death certificates and data of the national CF foundation. The study was confined to the years of birth 1961-1965. On a total of 1,239,566 live births 342 infants and children were found to have CF (1/3600). A list of all studies on the frequency of CF in Caucasian populations is presented as an appendix. A seasonal trend in the expression of the CF gene at birth (either with or without meconium ileus) was noted.
在荷兰，通过向815名医学专家（儿科医生、肺部专家和病理学家）进行询问，并分析医院入院数据、死亡证明以及国家囊性纤维化基金会的数据，开展了一项关于出生时囊性纤维化（CF）患病率的回顾性研究。该研究局限于1961年至1965年出生的年份。在总共1,239,566例活产中，发现342名婴儿和儿童患有CF（1/3600）。作为附录列出了所有关于白种人群体中CF发病率的研究。出生时CF基因表达（无论有无胎粪性肠梗阻）存在季节性趋势。
