1961年至1987年意大利热那亚矽肺患者的死亡率。

Mortality among silicotics in Genoa, Italy, from 1961 to 1987.

作者信息

Merlo F, Fontana L, Reggiardo G, Ceppi M, Barisione G, Garrone E, Doria M

机构信息

IST - Instituto Nazionale per la Ricerca sul Cancro, CSTA - Centre for the Study of Environmental Cancer, Division of Environmental Epidemiology and Biostatistics, Genoa, Italy.

出版信息

Scand J Work Environ Health. 1995;21 Suppl 2:77-80.

PMID:8929697

Abstract

A historical cohort mortality study conducted among 515 silicotic subjects revealed higher than expected risks for all causes [standardized mortality ratio (SMR) 1.89], respiratory tract diseases (SMR 8.89), silicotuberculosis (SMR 27.00), respiratory tract cancers (SMR 3.14), and lung cancer (SMR 3.50). Mortality from cardiovascular diseases was lower than that expected (SMR 0.51). Lung cancer risk increased with duration of occupational exposure (SMR 2.80, 2.99, and 5.02 for 14, 15-29, and 30 years of employment, respectively). Lung cancer risk was higher for the silicotics without tuberculosis (SMR 3.72) than for those with tuberculosis (SMR 2.83). Indirect adjustment for smoking habits, including number of cigarettes smoked per day, showed that smoking would have been responsible for a maximum risk of 1.77. Thus smoking may have explained 50% of the observed excess mortality from lung cancer.

摘要

一项针对515名矽肺患者开展的历史性队列死亡率研究显示，所有病因的风险均高于预期[标准化死亡比（SMR）为1.89]，呼吸道疾病（SMR为8.89）、矽肺结核（SMR为27.00）、呼吸道癌症（SMR为3.14）和肺癌（SMR为3.50）亦是如此。心血管疾病导致的死亡率低于预期（SMR为0.51）。肺癌风险随职业接触时间的延长而增加（工作14年、15 - 29年和30年的SMR分别为2.80、2.99和5.02）。未患结核病的矽肺患者的肺癌风险（SMR为3.72）高于患结核病的患者（SMR为2.83）。对吸烟习惯进行间接调整，包括每日吸烟量，结果显示吸烟导致的最大风险为1.77。因此，吸烟可能解释了观察到的肺癌超额死亡率的50%。