Sautter F J, McDermott B E, Cornwell J, Johnson J, Borges A, Wilson A F, Vasterling J J, Foundas A L
Tulane University Medical School, Department of Psychiatry and Neurology, New Orleans, LA 70112, USA.
Schizophr Res. 1995 Dec;18(1):1-7. doi: 10.1016/0920-9964(95)00015-1.
This exploratory study describes the heterogeneity of the neuropsychological deficits that characterize familial schizophrenia. Forty-six familial schizophrenics showed significantly more variability in abstraction and problem-solving and motor control than 39 non-familial schizophrenics. Cluster analyses of these two neuropsychological parameters indicate that while the non-familial schizophrenics fall into one homogeneous cluster, the familial schizophrenics fall into three relatively distinct clusters which differ significantly in their morbid risk for schizophrenic-spectrum disorder. These preliminary data suggest that frontal lobe deficits are associated with an increased familial risk for schizophrenia.
