Paz C, Huitron-Resendiz S
Departmento de Neurofisiologia, Instituto Nacional de Neurologia y Neurocirugia MVS, Mexico.
Neurosci Lett. 1996 Feb 2;204(1-2):49-52. doi: 10.1016/0304-3940(96)12313-2.
Polysomnographic studies were done at hourly intervals during 0.00, 0.35, 0.75 and 1.50 ppm of ozone (O3) exposure. We found a significant decrease in paradoxical sleep after 2 h and an increase in slow wave sleep after 12 h at all concentrations of O3. High resolution liquid chromatography demonstrated an increase in 5-HT concentration in the rat pons, in a roughly stepwise fashion as the O3 concentration increased. We propose that reaction products derived from O3 exposure, such as prostaglandins, could be affecting those physiological and biochemical mechanisms critical for the generation and maintenance of the sleep-wake cycle.
在暴露于0.00、0.35、0.75和1.50 ppm臭氧（O₃）期间，每隔一小时进行多导睡眠图研究。我们发现，在所有O₃浓度下，暴露2小时后异相睡眠显著减少，暴露12小时后慢波睡眠增加。高分辨率液相色谱显示，随着O₃浓度增加，大鼠脑桥中5-羟色胺浓度大致呈逐步上升趋势。我们认为，臭氧暴露产生的反应产物，如前列腺素，可能正在影响对睡眠-觉醒周期的产生和维持至关重要的那些生理和生化机制。
