Carretta D, Sbriccoli A, Santarelli M, Pinto F, Granato A, Minciacchi D
Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
Neurosci Lett. 1996 Feb 2;204(1-2):69-72. doi: 10.1016/0304-3940(96)12319-3.
The crossed thalamo-cortical and cortico-thalamic connections of the mouse are drawn using the tracer wheat germ agglutinin-horseradish peroxidase. After injections in the frontal cortex of the right hemisphere cells labeled retrogradely and axons labeled anterogradely are observed in the thalamus ipsilateral and contralateral to the cortical injections. The retrograde and anterograde labeling in the contralateral thalamus is less intense than ipsilaterally and involves the mediodorsal, ventral medial, central medial, and paracentral nuclei. Crossed fronto-thalamic axons reach more lateral regions than those containing contralateral thalamo-frontal neurons. Our results demonstrate that the thalamo-cortical system of mice has a bilateral component. The functional significance of this pathway and analogies with crossed thalamo-cortical connections in other species are discussed.
利用示踪剂小麦胚凝集素-辣根过氧化物酶绘制了小鼠的交叉丘脑-皮质和皮质-丘脑连接。在右半球额叶皮质注射后，在皮质注射同侧和对侧的丘脑中观察到逆行标记的细胞和顺行标记的轴突。对侧丘脑中的逆行和顺行标记比同侧的弱，且涉及背内侧、腹内侧、中央内侧和中央旁核。交叉的额-丘脑轴突到达的外侧区域比含有对侧丘脑-额叶神经元的区域更靠外侧。我们的结果表明，小鼠的丘脑-皮质系统具有双侧成分。讨论了该通路的功能意义以及与其他物种交叉丘脑-皮质连接的相似之处。
