Frankfurt M, McKittrick C R, McEwen B S, Luine V N
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA.
Brain Res. 1995 Oct 23;696(1-2):1-6. doi: 10.1016/0006-8993(95)00663-b.
Tianeptine is an atypical tricyclic antidepressant that facilitates serotonin (5-HT) reuptake. Tianeptine (10 mg/kg) or saline was administered intraperitoneally to male rats daily for 4 days. Monoamine levels were measured in micropunches of discrete brain nuclei that are implicated in mood and cognition. In addition, the rates of 5-HT and norepinephrine (NE) accumulation were determined by the pargyline method. Few changes were noted in the 5-HT system. 5-HT levels were increased by short-term tianeptine in the CA3 region of hippocampus, and 5-hydroxyindoleacetic acid (5-HIAA) was increased in the ventromedial nucleus of hypothalamus, while 5-HT turnover was decreased in preoptic area (POA). In addition, short-term tianeptine treatment increased NE levels in POA, parietal sensory cortex (SCTX) and dorsal raphe (DR), and decreased NE in dentate gyrus. NE turnover was also decreased in DR, SCTX and parietal motor cortex. These data suggest that the short-term neural and behavioral actions of tianeptine may be attributable, in part, to alterations of the norepinephrine system.
噻奈普汀是一种促进血清素（5-羟色胺）再摄取的非典型三环类抗抑郁药。将噻奈普汀（10毫克/千克）或生理盐水每天腹腔注射给雄性大鼠，持续4天。在与情绪和认知有关的离散脑核的微量穿孔中测量单胺水平。此外，采用帕吉林法测定5-羟色胺和去甲肾上腺素（NE）的积累速率。5-羟色胺系统中未见明显变化。短期使用噻奈普汀可使海马体CA3区的5-羟色胺水平升高，下丘脑腹内侧核的5-羟吲哚乙酸（5-HIAA）增加，而视前区（POA）的5-羟色胺周转率降低。此外，短期噻奈普汀治疗可使POA、顶叶感觉皮层（SCTX）和中缝背核（DR）的去甲肾上腺素水平升高，齿状回的去甲肾上腺素水平降低。DR、SCTX和顶叶运动皮层的去甲肾上腺素周转率也降低。这些数据表明，噻奈普汀的短期神经和行为作用可能部分归因于去甲肾上腺素系统的改变。
