Hajós M, Sharp T, Newberry N R
Oxford University Department of Clinical Pharmacology, Radcliffe Infirmary, UK.
Brain Res. 1996 Oct 21;737(1-2):308-12. doi: 10.1016/0006-8993(96)00936-5.
Here we report the existence of burst-firing neurones in the rat dorsal raphe as detected in vivo using intracellular electrophysiological techniques. These neurones discharged single action potentials and doublets or triplets of action potentials in a slow and regular pattern. The apparent input resistance, action potential width and firing threshold of these burst-firing raphe neurones were indistinguishable from classical 5-HT neurones. Spike doublets were evoked by depolarising DC currents, but only in burst-firing neurones. These findings provide further evidence to support the hypothesis that 5-HT neurones (or a sub-set of them) are capable of burst-firing activity.
在此，我们报告利用细胞内电生理技术在活体大鼠中检测到背侧中缝核存在爆发式放电神经元。这些神经元以缓慢且规律的模式发放单动作电位以及动作电位的双峰或三峰。这些爆发式放电中缝核神经元的表观输入电阻、动作电位宽度和放电阈值与经典5-羟色胺能神经元并无差异。去极化直流电流可诱发峰电位双峰，但仅在爆发式放电神经元中出现。这些发现为支持5-羟色胺能神经元（或其中一部分）能够进行爆发式放电活动这一假说提供了进一步的证据。
