Irshad M, Acharya S K
Department of Laboratory Medicine and Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Eur J Gastroenterol Hepatol. 1996 Oct;8(10):995-8. doi: 10.1097/00042737-199610000-00011.
Preliminary reports indicate that hepatitis D virus (HDV) infection exists in India. However, its prevalence in patients with different types of liver diseases has not been studied in detail. The aim of this study was to evaluate the status of HDV infection in severe types of liver disease in India.
Using commercial kits for various hepatitis viral markers, the present study was undertaken to determine the serological status of hepatitis B virus (HBV) and hepatitis D virus (HDV) markers in 208 patients with severe liver diseases. This total included 110 cases with fulminant hepatic failure (FHF), 65 cases with subacute hepatic failure (SHF) and 33 cases with chronic active hepatitis (CAH).
The hepatitis B surface antigen (HBsAg) carrier population, indicated by the presence of HBsAg without IgM anti-HBc (hepatitis B core) in serum, was recorded in 23.6%, 24.6% and 60.6% cases of FHF, SHF and CAH groups, respectively. HBV infection, as indicated by serum positivity of IgM anti-HBc in the FHF and SHF groups and HBsAg and/or IgM anti-HBc in the CAH group, was detected in 19.1%, 23.1% and 69.7% of cases from these three groups, respectively. IgM anti-HDV, demonstrating active/recent HDV infection, was found in 8.1% cases of FHF and 9.2% cases of SHF patients. HDV as a superinfection in HBsAg carriers was noted in 4.5% and 4.6% cases, respectively of FHF and SHF groups. Similarly, HDV-HBV coinfection, diagnosed by simultaneous presence of IgM anti-HBc and IgM anti-HDV in the FHF and SHF groups, was recorded in 3.6% and 4.6% of cases from these two groups, respectively. In the CAH group, HDV infection was observed in 9.2% cases.
HDV infection, recorded in less than 10% of patients with different liver diseases in India, seems to be an unimportant factor in inducing severe liver diseases in this country.
初步报告表明，丁型肝炎病毒（HDV）感染在印度存在。然而，其在不同类型肝病患者中的流行情况尚未得到详细研究。本研究的目的是评估印度严重肝病中HDV感染的状况。
使用针对各种肝炎病毒标志物的商业试剂盒，本研究旨在确定208例严重肝病患者中乙型肝炎病毒（HBV）和丁型肝炎病毒（HDV）标志物的血清学状况。这总共包括110例暴发性肝衰竭（FHF）患者、65例亚急性肝衰竭（SHF）患者和33例慢性活动性肝炎（CAH）患者。
血清中存在乙肝表面抗原（HBsAg）而无IgM抗-HBc（乙肝核心抗体）所表明的HBsAg携带者人群，在FHF组、SHF组和CAH组中分别占23.6%、24.6%和60.6%。FHF组和SHF组中IgM抗-HBc血清阳性以及CAH组中HBsAg和/或IgM抗-HBc所表明的HBV感染，在这三组患者中分别占19.1%、23.1%和69.7%。显示活跃/近期HDV感染的IgM抗-HDV，在FHF患者中占8.1%，在SHF患者中占9.2%。HDV作为HBsAg携带者的重叠感染，在FHF组和SHF组中分别占4.5%和4.6%。同样，FHF组和SHF组中通过同时存在IgM抗-HBc和IgM抗-HDV诊断的HDV-HBV合并感染，在这两组患者中分别占3.6%和4.6%。在CAH组中，9.2%的患者观察到HDV感染。
在印度，HDV感染在不到10%的不同肝病患者中被记录到，似乎不是该国导致严重肝病的重要因素。
