Lord S R, Ward J A, Williams P, Zivanovic E
Prince of Wales Medical Research Institute, Randwick, NSW, Australia.
Osteoporos Int. 1996;6(5):361-7. doi: 10.1007/BF01623009.
One hundred and seventy-nine women aged 60-85 years (mean age 71.6 years, SD 5.3 years) were randomly recruited from the community to participate in a 12-month randomized controlled trial to determine whether a program of twice-weekly structured exercise has beneficial effects on three factors associated with osteoporotic fractures: quadriceps strength, postural sway and bone density. At initial testing, there were no significant differences in the strength, sway and bone density measures (assessed at the hip and lumbar spine) between the exerciser and control groups. The exercise classes included strengthening, coordination and balance exercises, and approximately 35 min of each class comprised weight-bearing exercise. The mean number of classes attended for the 68 exercisers who completed the program was 59.8 of the 82 classes (72.9%). At the completion of the trial, the intervention group showed significant improvements in quadriceps strength and sway but not bone mineral density when compared with the control group. Indices of fracture risk, indicated by (i) the sum of standard score results and (ii) the sum of quartile grades of the femoral neck bone density, sway and strength measures, decreased significantly in the exercisers at the end of the trial compared with the controls. In conclusion, the program of general aerobic exercise may have reduced overall fracture risk, even though it did not significantly increase bone density. Further long-term studies are required that include acceptable weight-loaded exercises to determine optimal programs for reducing fracture risk factors by improving bone density as well as strength and balance.
179名年龄在60 - 85岁之间(平均年龄71.6岁,标准差5.3岁)的女性从社区中随机招募,参与一项为期12个月的随机对照试验,以确定每周两次的结构化锻炼计划是否对与骨质疏松性骨折相关的三个因素有有益影响:股四头肌力量、姿势摆动和骨密度。在初始测试时,锻炼组和对照组在力量、摆动和骨密度测量值(在髋部和腰椎进行评估)方面没有显著差异。锻炼课程包括强化、协调和平衡练习,每节课约35分钟为负重练习。完成该计划的68名锻炼者参加课程的平均数量为82节课中的59.8节(72.9%)。在试验结束时,与对照组相比,干预组在股四头肌力量和摆动方面有显著改善,但骨矿物质密度没有改善。由(i)标准分数结果总和以及(ii)股骨颈骨密度、摆动和力量测量值的四分位数等级总和所表示的骨折风险指数,在试验结束时锻炼者与对照组相比显著降低。总之,一般有氧运动计划可能降低了总体骨折风险,尽管它没有显著增加骨密度。需要进一步的长期研究,包括可接受的负重练习,以确定通过改善骨密度以及力量和平衡来降低骨折风险因素的最佳计划。