重度抗阻训练对骨量低至极低的绝经后女性是安全的，且能改善骨骼、功能和身高：LIFTMOR试验的新早期发现。
Heavy resistance training is safe and improves bone, function, and stature in postmenopausal women with low to very low bone mass: novel early findings from the LIFTMOR trial.
作者信息
Watson S L, Weeks B K, Weis L J, Horan S A, Beck B R
机构信息
School of Allied Health Sciences, Gold Coast Campus, Griffith University, Southport, QLD, 4222, Australia.
Centre for Musculoskeletal Research, Menzies Health Institute Queensland, Gold Coast, Queensland, Australia.
出版信息
Osteoporos Int. 2015 Dec;26(12):2889-94. doi: 10.1007/s00198-015-3263-2. Epub 2015 Aug 5.
UNLABELLED
The aim of the LIFTMOR (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation) trial is to determine the safety and efficacy of brief, bone-targeted, high-intensity progressive resistance training (HiPRT) with impact loading for postmenopausal women with low bone mass. Preliminary findings indicate the LIFTMOR program is safe and effective.
INTRODUCTION
Despite a lack of notable efficacy, exercise guidelines for osteoporosis typically recommend moderate-intensity exercises, owing to a perceived risk of fracture from high-intensity loading. Indeed, safety concerns alone have prevented the well-recognised preferential response of bone tissue to high-intensity loads from being applied to those who stand to benefit the most. To progress from this therapeutic stalemate, a challenge to conventional wisdom was required. Our goal was to examine the safety and efficacy of HiPRT and impact loading for risk factors of osteoporotic fracture in postmenopausal women with low to very low bone mass.
METHODS
Participants have been randomised to either 8 months of twice-weekly 30-min supervised HiPRT and impact loading or a low-intensity home-based exercise program of the same duration and dose. Testing at baseline and follow-up has included anthropometry; bone, muscle, and fat mass; and functional performance.
RESULTS
Twenty-eight women (66.1 ± 4.8 years, mean lumbar spine T-score -2.15 ± 0.72) have completed the study. HiPRT and impact loading (n = 12) improved height (0.4 ± 0.2 cm vs -0.3 ± 0.1 cm, p = 0.003), femoral neck bone mineral density (0.3 ± 0.5 % vs -2.5 ± 0.8 %, p = 0.016), lumbar spine bone mineral density (1.6 ± 0.9 % vs -1.7 ± 0.6 %, p = 0.005), and functional performance (p < 0.05), compared to controls (n = 16). Compliance has been >87 %. There have been no injuries.
CONCLUSIONS
Brief supervised HiPRT with impact loading is a safe and effective exercise therapy for postmenopausal women with low to very low bone mass.
未标注
LIFTMOR（用于训练肌肉和骨质疏松症康复的提升干预）试验的目的是确定针对低骨量绝经后女性进行简短、以骨骼为目标的高强度渐进性抗阻训练（HiPRT）并结合冲击负荷的安全性和有效性。初步研究结果表明LIFTMOR方案是安全有效的。
引言
尽管缺乏显著疗效，但由于认为高强度负荷存在骨折风险，骨质疏松症运动指南通常推荐中等强度运动。事实上，仅安全问题就阻碍了骨组织对高强度负荷的公认优先反应应用于最能从中受益的人群。为了打破这种治疗僵局，需要对传统观念提出挑战。我们的目标是研究HiPRT和冲击负荷对低骨量至极低骨量绝经后女性骨质疏松性骨折危险因素的安全性和有效性。
方法
参与者被随机分为两组，一组进行为期8个月、每周两次、每次30分钟的有监督的HiPRT和冲击负荷训练，另一组进行为期相同、剂量相同的低强度家庭锻炼计划。基线和随访测试包括人体测量、骨骼、肌肉和脂肪量以及功能表现。
结果
28名女性（66.1±4.8岁，平均腰椎T值-2.15±0.72）完成了研究。与对照组（n=16）相比，HiPRT和冲击负荷训练组（n=12）的身高（0.4±0.2厘米对-0.3±0.1厘米，p=0.003）、股骨颈骨密度（0.3±0.5%对-2.5±0.8%，p=0.016）、腰椎骨密度（1.6±0.9%对-1.7±0.6%，p=0.005）和功能表现（p<0.05）均有改善。依从性>87%。未发生损伤。
结论
对于低骨量至极低骨量的绝经后女性，简短的有监督HiPRT并结合冲击负荷是一种安全有效的运动疗法。
Zotero 插件