Montagna M, Serova O, Sylla B S, Mattei M G, Lenoir G M
International Agency for Research on Cancer, Lyon, France.
Hum Genet. 1996 Dec;98(6):738-40. doi: 10.1007/s004390050295.
The h-PRL-1 gene codes for a new phosphotyrosine phosphatase that may play an important role in the control of basic cellular processes such as cell growth and proliferation. Using the cDNA of the h-PRL-1 gene as a probe, we examined a somatic mouse and hamster x human hybrid panel and found that chromosomes 1, 17 and 11 harbor sequences homologous to h-PRL-1. By in situ hybridization of metaphase spreads, subchromosomal localizations were determined at bands 1p35-p34, 17q12-q21 and 11q24-q25; in addition, a faint signal was detected at 12q24. The chromosomal assignment of the genes homologous to h-PRL-1 will help the investigation of its possible involvement in human diseases involving genetic alteration at these chromosomal regions.
h-PRL-1基因编码一种新的磷酸酪氨酸磷酸酶，它可能在诸如细胞生长和增殖等基本细胞过程的控制中发挥重要作用。我们以h-PRL-1基因的cDNA为探针，检测了一个体细胞小鼠和仓鼠与人的杂交细胞系，发现1号、17号和11号染色体含有与h-PRL-1同源的序列。通过中期染色体铺展的原位杂交，确定了亚染色体定位在1p35-p34、17q12-q21和11q24-q25带；此外，在12q24处检测到微弱信号。与h-PRL-1同源的基因的染色体定位将有助于研究其可能参与这些染色体区域发生遗传改变的人类疾病。
