Higley J D, Mehlman P T, Poland R E, Taub D M, Vickers J, Suomi S J, Linnoila M
Laboratory of Clinical Studies, DICBR, NIAAA, Bethesda, Maryland, MH 00534, USA.
Biol Psychiatry. 1996 Dec 1;40(11):1067-82. doi: 10.1016/S0006-3223(95)00675-3.
We studied the potential roles of testosterone and serotonin in various forms of aggressive and violent behaviors by measuring each biochemical and behaviour in free-ranging adolescent male nonhuman primates. Our results showed that (1) CSF free testosterone concentrations were positively correlated with overall aggressiveness, but not with measures of impulsivity. (2) CSF 5-HIAA concentrations were negatively correlated with impulsive behavior, and severe, unrestrained aggression, but not with overall rates of aggression. High rates of impulsive behavior were positively correlated with severe, unrestrained aggression, but not overall rates of aggression. (3) Dimensional analyses showed that while subjects with low CSF 5-HIAA exhibited high rates of aggression, high CSF testosterone further augmented rates and intensity of aggression in subjects with low CSF 5-HIAA. We conclude that high CSF free testosterone concentrations are associated with competitive aggression, while low CSF 5-HIAA concentrations are associated with severe aggression which results from impaired impulse control, and perseverance.
我们通过测量自由放养的青春期雄性非人类灵长类动物的每种生化指标和行为，研究了睾酮和血清素在各种形式的攻击和暴力行为中的潜在作用。我们的结果表明：（1）脑脊液中游离睾酮浓度与总体攻击性呈正相关，但与冲动性指标无关。（2）脑脊液中5-羟吲哚乙酸浓度与冲动行为以及严重的、无节制的攻击呈负相关，但与总体攻击率无关。高频率的冲动行为与严重的、无节制的攻击呈正相关，但与总体攻击率无关。（3）维度分析表明，脑脊液中5-羟吲哚乙酸水平低的受试者表现出较高的攻击率，而脑脊液睾酮水平高会进一步增加脑脊液中5-羟吲哚乙酸水平低的受试者的攻击率和攻击强度。我们得出结论，脑脊液中游离睾酮浓度高与竞争性攻击有关，而脑脊液中5-羟吲哚乙酸浓度低与因冲动控制受损和执着导致的严重攻击有关。
