Aine L
Department of Oral and Maxillofacial Surgery, Tampere University Hospital, Finland.
Ann Med. 1996 Feb;28(1):9-12. doi: 10.3109/07853899608999067.
Systematic and chronologically distributed permanent-tooth so-called coeliac-type enamel defects are highly prevalent both in children and adults with coeliac disease (gluten-sensitive enteropathy) and dermatitis herpetiformis. Coeliac-type enamel defects were also found in healthy first-degree family members of coeliac disease patients. Our family study showed that these persons with the typical defected enamel were genetically similar to coeliac disease patients (A1;B8;DR3). As coeliac disease patients are often clinically silent with no gastrointestinal symptoms, or they complain only of minimal abdominal discomfort, both dentists and physicians could select patients with coeliac-type enamel defects for gastroenterological and dermatological consultations, including serological screening tests and later jejunal mucosal biopsy.
在患有乳糜泻（麸质敏感性肠病）和疱疹样皮炎的儿童及成人中，系统性且按时间顺序分布的所谓乳糜泻型恒牙釉质缺陷极为普遍。在乳糜泻患者的健康一级亲属中也发现了乳糜泻型釉质缺陷。我们的家族研究表明，这些具有典型釉质缺陷的人与乳糜泻患者在基因上相似（A1；B8；DR3）。由于乳糜泻患者临床上通常无症状或无胃肠道症状，或者仅主诉轻微腹部不适，因此牙医和医生都可以选择有乳糜泻型釉质缺陷的患者进行胃肠病学和皮肤病学会诊，包括血清学筛查试验以及随后的空肠黏膜活检。
