• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays.叙利亚仓鼠胚胎细胞转化试验在预测国家毒理学计划目前正在啮齿动物生物测定中测试的化学物质致癌性方面的应用。
Environ Health Perspect. 1996 Oct;104 Suppl 5(Suppl 5):1075-84. doi: 10.1289/ehp.96104s51075.
2
The syrian hamster embryo (SHE) cell transformation assay: review of the methods and results.叙利亚仓鼠胚胎（SHE）细胞转化试验：方法与结果综述
Toxicol Pathol. 2001;29 Suppl:138-46. doi: 10.1080/019262301753178546.
3
Comparison of the standard and reduced pH Syrian hamster embryo (SHE) cell in vitro transformation assays in predicting the carcinogenic potential of chemicals.标准pH值与降低pH值的叙利亚仓鼠胚胎（SHE）细胞体外转化试验在预测化学物质致癌潜力方面的比较。
Mutat Res. 1996 Sep 21;356(1):11-63. doi: 10.1016/0027-5107(95)00197-2.
4
Use of the Syrian hamster embryo cell transformation assay for determining the carcinogenic potential of heavy metal compounds.使用叙利亚仓鼠胚胎细胞转化试验来确定重金属化合物的致癌潜力。
Fundam Appl Toxicol. 1996 Nov;34(1):67-72. doi: 10.1006/faat.1996.0176.
5
Use of Syrian hamster embryo and BALB/c 3T3 cell transformation for assessing the carcinogenic potential of chemicals.利用叙利亚仓鼠胚胎和BALB/c 3T3细胞转化来评估化学物质的致癌潜力。
IARC Sci Publ. 1999(146):409-25.
6
The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals.用于评估化学物质致癌潜力的pH 6.7叙利亚仓鼠胚胎细胞转化试验。
Mutat Res. 1996 Sep 21;356(1):85-127. doi: 10.1016/0027-5107(95)00199-9.
7
The testing of chemicals in the Syrian hamster embryo (SHE) cell transformation assay for assessment of carcinogenic potential.在叙利亚仓鼠胚胎（SHE）细胞转化试验中对化学物质进行检测，以评估其致癌潜力。
Toxicol In Vitro. 2004 Apr;18(2):213-8. doi: 10.1016/j.tiv.2003.08.001.
8
Induction of micronuclei in Syrian hamster embryo cells: comparison to results in the SHE cell transformation assay for National Toxicology Program test chemicals.叙利亚仓鼠胚胎细胞中微核的诱导：与国家毒理学计划测试化学品的SHE细胞转化试验结果的比较。
Mutat Res. 1997 Aug 1;392(1-2):61-70. doi: 10.1016/s0165-1218(97)00045-1.
9
Cell transformation assays.细胞转化试验。
Curr Protoc Toxicol. 2001 May;Chapter 3:Unit3.4. doi: 10.1002/0471140856.tx0304s01.
10
The low pH Syrian hamster embryo (SHE) cell transformation assay: a revitalized role in carcinogen prediction.低pH值叙利亚仓鼠胚胎（SHE）细胞转化试验：在致癌物预测中的新作用。
Mutat Res. 1996 Sep 21;356(1):5-9. doi: 10.1016/0027-5107(95)00196-4.

引用本文的文献

1
Detailed hazard assessment of ethylbenzene to establish an indoor air quality guideline in Japan.日本乙苯详细危害评估以制定室内空气质量指南。
Environ Health Prev Med. 2025;30:34. doi: 10.1265/ehpm.24-00415.
2
Safety and efficacy of a feed additive consisting of an essential oil from the leaves of L. (laurel leaf oil) for all animal species (FEFANA asbl).一种由月桂叶精油组成的饲料添加剂对所有动物物种的安全性和有效性（FEFANA asbl）
EFSA J. 2023 Mar 9;21(3):e07875. doi: 10.2903/j.efsa.2023.7875. eCollection 2023 Mar.
3
Safety and efficacy of feed additives consisting of essential oils from the bark and the leaves of J. Presl (cinnamon bark oil and cinnamon leaf oil) for use in all animal species (FEFANA asbl).由樟科月桂属植物树皮和树叶中的精油（桂皮油和桂叶油）组成的饲料添加剂用于所有动物物种的安全性和有效性（欧洲动物营养添加剂和预混料协会）
EFSA J. 2022 Oct 25;20(10):e07601. doi: 10.2903/j.efsa.2022.7601. eCollection 2022 Oct.
4
Safety and efficacy of a feed additive consisting of an essential oil from the leaves of (P.J. Bergius) Pillans (buchu leaf oil) for use in all animal species (FEFANA asbl).一种由（P.J. 贝吉乌斯）皮兰斯（布枯叶油）叶中的精油组成的饲料添加剂用于所有动物物种的安全性和有效性（欧洲动物营养添加剂和预混料协会）
EFSA J. 2022 Mar 8;20(3):e07160. doi: 10.2903/j.efsa.2022.7160. eCollection 2022 Mar.
5
Safety and efficacy of a feed additive consisting of a tincture from the bark of J. Presl (cinnamon tincture) for use in all animal species (FEFANA asbl).一种由樟科楠木树皮酊剂（肉桂酊剂）组成的饲料添加剂用于所有动物物种的安全性和有效性（欧洲饲料添加剂和预混料协会）
EFSA J. 2021 Dec 9;19(12):e06986. doi: 10.2903/j.efsa.2021.6986. eCollection 2021 Dec.
6
p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing.p53诱导作为对25种正在进行体内致癌性测试的化学物质的遗传毒性测试。
Environ Health Perspect. 1999 Oct;107(10):805-12. doi: 10.1289/ehp.99107805.
7
Comparison of 17 methods of predicting the carcinogenicity of 30 chemicals.30种化学物质致癌性预测的17种方法比较。
Environ Health Perspect. 1997 May;105(5):466-7. doi: 10.1289/ehp.105-1469875.
8
The NIEHS Predictive-Toxicology Evaluation Project.美国国家环境健康科学研究所预测毒理学评估项目
Environ Health Perspect. 1996 Oct;104 Suppl 5(Suppl 5):1001-10. doi: 10.1289/ehp.96104s51001.

本文引用的文献

1
Growth factor responsiveness and alterations in growth factor homeostasis in Syrian hamster embryo cells during in vitro transformation.叙利亚仓鼠胚胎细胞在体外转化过程中的生长因子反应性及生长因子稳态变化
Carcinogenesis. 1994 Jun;15(6):1203-9. doi: 10.1093/carcin/15.6.1203.
2
Use of cell transformation systems for carcinogenicity testing and mechanistic studies of carcinogenesis.细胞转化系统在致癌性测试和致癌作用机制研究中的应用。
Pharmacol Rev. 1984 Jun;36(2 Suppl):53S-70S.
3
In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons.致癌碳氢化合物使正常细胞在体外转化为肿瘤细胞。
J Natl Cancer Inst. 1965 Oct;35(4):641-61.
4
An interlaboratory comparison of enhanced morphological transformation of Syrian hamster embryo cells cultured under conditions of reduced bicarbonate concentration and pH.在降低碳酸氢盐浓度和pH值条件下培养的叙利亚仓鼠胚胎细胞增强形态转化的实验室间比较。
Mutat Res. 1989 Mar;222(3):205-18. doi: 10.1016/0165-1218(89)90136-5.
5
The progressive nature of neoplastic transformation of Syrian hamster embryo cells in culture.叙利亚仓鼠胚胎细胞在培养中肿瘤转化的渐进性。
Prog Exp Tumor Res. 1979;24:17-27. doi: 10.1159/000402080.

叙利亚仓鼠胚胎细胞转化试验在预测国家毒理学计划目前正在啮齿动物生物测定中测试的化学物质致癌性方面的应用。

Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays.

作者信息

Kerckaert G A, Brauninger R, LeBoeuf R A, Isfort R J

机构信息

Procter & Gamble Co., Cincinnati, Ohio 45253-8707, USA.

出版信息

Environ Health Perspect. 1996 Oct;104 Suppl 5(Suppl 5):1075-84. doi: 10.1289/ehp.96104s51075.

DOI:10.1289/ehp.96104s51075
PMID:8933057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1469685/
Abstract

The Syrian hamster embryo (SHE) cell transformation assay was used to predict the carcinogenicity of 26 chemicals currently being tested in the rodent bioassay by the National Toxicology Program as part of its program titled "Strategies for Predicting Chemical Carcinogenesis in Rodents." Of these 26 chemicals, 17 were found to be positive in the SHE cell transformation assay while 9 were negative. Carcinogenicity predictions were made for these chemicals, based upon the SHE cell transformation assay results. Our predictions will be compared with the rodent bioassay results as they become available.

摘要

叙利亚仓鼠胚胎（SHE）细胞转化试验被用于预测26种化学物质的致癌性，这些化学物质目前正在由国家毒理学计划进行啮齿动物生物测定测试，作为其名为“预测啮齿动物化学致癌作用的策略”项目的一部分。在这26种化学物质中，17种在SHE细胞转化试验中呈阳性，而9种呈阴性。根据SHE细胞转化试验结果对这些化学物质进行了致癌性预测。我们的预测将与啮齿动物生物测定结果进行比较，一旦结果可用。