叙利亚仓鼠胚胎细胞转化试验在预测国家毒理学计划目前正在啮齿动物生物测定中测试的化学物质致癌性方面的应用。
Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays.
作者信息
Kerckaert G A, Brauninger R, LeBoeuf R A, Isfort R J
机构信息
Procter & Gamble Co., Cincinnati, Ohio 45253-8707, USA.
出版信息
Environ Health Perspect. 1996 Oct;104 Suppl 5(Suppl 5):1075-84. doi: 10.1289/ehp.96104s51075.
Abstract
The Syrian hamster embryo (SHE) cell transformation assay was used to predict the carcinogenicity of 26 chemicals currently being tested in the rodent bioassay by the National Toxicology Program as part of its program titled "Strategies for Predicting Chemical Carcinogenesis in Rodents." Of these 26 chemicals, 17 were found to be positive in the SHE cell transformation assay while 9 were negative. Carcinogenicity predictions were made for these chemicals, based upon the SHE cell transformation assay results. Our predictions will be compared with the rodent bioassay results as they become available.
摘要
叙利亚仓鼠胚胎（SHE）细胞转化试验被用于预测26种化学物质的致癌性，这些化学物质目前正在由国家毒理学计划进行啮齿动物生物测定测试，作为其名为“预测啮齿动物化学致癌作用的策略”项目的一部分。在这26种化学物质中，17种在SHE细胞转化试验中呈阳性，而9种呈阴性。根据SHE细胞转化试验结果对这些化学物质进行了致癌性预测。我们的预测将与啮齿动物生物测定结果进行比较，一旦结果可用。
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本文引用的文献
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